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Lookup NU author(s): Joshua Ratliffe,
Dr Tetsushi Kataura,
Dr Viktor Korolchuk
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors. BioEssays published by Wiley Periodicals LLC. Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age-related diseases associated with impaired autophagy and oxidative stress.
Author(s): Ratliffe J, Kataura T, Otten EG, Korolchuk VI
Publication type: Review
Publication status: Published
Pages: Epub ahead of print
Online publication date: 21/08/2023
Acceptance date: 02/08/2023
ISSN (print): 0265-9247
ISSN (electronic): 1521-1878
Publisher: John Wiley and Sons Inc
PubMed id: 37603398