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Lookup NU author(s): Professor Bob Anderson,
Dr Simon BamforthORCiD
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© The Author(s), 2023. Published by Cambridge University Press.Controversies continue as to how many pharyngeal arches, with their contained arteries, are to be found in the developing human. Resolving these controversies is of significance to paediatric cardiologists since many investigating abnormalities of the extrapericardial arterial pathways interpret their findings on the basis of persistence of a fifth set of such arteries within an overall complement of six sets. The evidence supporting such an interpretation is open to question. In this review, we present the history of the existence of six such arteries, emphasising that the initial accounts of human development had provided evidence for the existence of only five sets. We summarise the current evidence that substantiates these initial findings. We then show that the lesions interpreted on the basis of persistence of the non-existing fifth arch arteries are well described on the basis of the persistence of collateral channels, known to exist during normal development, or alternatively due to remodelling of the aortic sac.
Author(s): Anderson RH, Graham A, Hikspoors JPJM, Lamers WH, Bamforth SD
Publication type: Review
Publication status: Published
Journal: Cardiology in the Young
Online publication date: 06/10/2023
Acceptance date: 17/08/2023
ISSN (print): 1047-9511
ISSN (electronic): 1467-1107
Publisher: Cambridge University Press
PubMed id: 37800310