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The assembly line enzymology of polyketide biosynthesis

Lookup NU author(s): Professor Paul RaceORCiD


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© Springer Science+Business Media New York 2016. Polyketides are a structurally and functionally diverse family of bioactive natural products that have found widespread application as pharmaceuticals, agrochemicals, and veterinary medicines. In bacteria complex polyketides are biosynthesized by giant multifunctional megaenzymes, termed modular polyketide synthases (PKSs), which construct their products in a highly coordinated assembly line-like fashion from a pool of simple precursor substrates. Not only is the multifaceted enzymology of PKSs a fascinating target for study, but it also presents considerable opportunities for the reengineering of these systems affording access to functionally optimized unnatural natural products. Here we provide an introductory primer to modular polyketide synthase structure and function, and highlight recent advances in the characterization and exploitation of these systems.

Publication metadata

Author(s): Till M, Race PR

Editor(s): Bradley S. Evans

Publication type: Book Chapter

Publication status: Published

Book Title: Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols

Year: 2016

Volume: 1401

Pages: 31-49

Online publication date: 02/02/2016

Acceptance date: 01/01/1900

Series Title: Methods in Molecular Biology

Publisher: Humana Press Inc.

Place Published: New York


DOI: 10.1007/978-1-4939-3375-4_2

PubMed id: 26831699

Library holdings: Search Newcastle University Library for this item

ISBN: 9781493933730