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A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

Copyright © 2024 Elsevier Ltd. All rights reserved.With the hope that disease-modifying treatments could target the molecular basis of Parkinson's disease, even before the onset of symptoms, we propose a biologically based classification. Our classification acknowledges the complexity and heterogeneity of the disease by use of a three-component system (SynNeurGe): presence or absence of pathological α-synuclein (S) in tissues or CSF; evidence of underlying neurodegeneration (N) defined by neuroimaging procedures; and documentation of pathogenic gene variants (G) that cause or strongly predispose to Parkinson's disease. These three components are linked to a clinical component (C), defined either by a single high-specificity clinical feature or by multiple lower-specificity clinical features. The use of a biological classification will enable advances in both basic and clinical research, and move the field closer to the precision medicine required to develop disease-modifying therapies. We emphasise the initial application of these criteria exclusively for research. We acknowledge its ethical implications, its limitations, and the need for prospective validation in future studies.

Publication metadata

Author(s): Hoglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE

Publication type: Review

Publication status: Published

Journal: The Lancet. Neurology

Year: 2024

Volume: 23

Issue: 2

Pages: 191-204

Acceptance date: 02/04/2018

ISSN (electronic): 1474-4422

URL: https://doi.org/10.1016/S1474-4422(23)00404-0

DOI: 10.1016/S1474-4422(23)00404-0

PubMed id: 38267191

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