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Lookup NU author(s): Dr Corey ChanORCiD, Dr James KnightORCiD
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approaches in particular demonstrating high clinical efficacy.Despite advancements in the accuracy in pre-operative imaging, translation of an image to surgical margins is difficult, regularly resulting in wider resection margins than required. For soft tissue sarcomas there is currently no standard technique for image guided resections, while for bone sarcomas fluoroscopy may be used, however margins are not easily discernible during the surgical procedure. Near infra-red (NIR) fluorescence guided surgery offers an intra-operative modality through which complete tumour resection with adequate tumour-free margins may be achieved, while simultaneously minimising surgical morbidity.NIR imaging presents a potentially valuable adjunct to sarcoma surgery. Early reports indicate that it may be able to provide the surgeon with helpful information on anatomy, perfusion, lymphatic drainage, tumour margins and metastases. The use of NIR fluorochromes have also been demonstrated to be well tolerated by patients. However, prior to widespread implementation, studies related to cost-effectiveness and the development of protocols are essential. Nevertheless, NIR imaging may become ubiquitous in the future, carrying the potential to transform the surgical management of sarcoma.
Author(s): Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS
Publication type: Article
Publication status: Published
Journal: Cancer Letters
Year: 2020
Volume: 483
Pages: 1-11
Print publication date: 28/07/2025
Online publication date: 02/04/2020
Acceptance date: 29/03/2020
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
Publisher: Elsevier Ireland Ltd.
URL: https://doi.org/10.1016/j.canlet.2020.03.029
DOI: 10.1016/j.canlet.2020.03.029
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