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Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

Lookup NU author(s): Professor Anthony MoormanORCiD

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Abstract

© 2024 American Society of HematologyT-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy.

Publication metadata

Author(s): O'Connor D, Valle-Inclan JE, Conde L, Bloye G, Rahman S, Costa JR, Bartram J, Adams S, Wright G, Elrick H, Wall K, Dyer S, Howell C, Jigoulina G, Herrero J, Cortes-Ciriano I, Moorman AV, Mansour MR

Publication type: Article

Publication status: Published

Journal: Blood

Year: 2024

Volume: 143

Issue: 10

Pages: 933-937

Print publication date: 07/03/2024

Online publication date: 09/01/2024

Acceptance date: 01/12/2023

ISSN (print): 0006-4971

ISSN (electronic): 1528-0020

Publisher: Elsevier B.V.

URL: https://doi.org/10.1182/blood.2023021906

DOI: 10.1182/blood.2023021906

PubMed id: 38194681

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