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Apixaban overdose in children: case report and proposed management. A brief communication from the Pediatric and Neonatal Thrombosis and Hemostasis SSC of ISTH

Lookup NU author(s): Dr Tina Biss

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Abstract

© 2024 The Authors. Background: Direct oral anticoagulants are commonly prescribed for adults and increasingly also for children requiring anticoagulation therapy. While household medications should not be accessible to children, accidental, and intentional overdoses occur. Key Clinical Question: How should apixaban overdose in children be managed?. Clinical Approach: We present a case of an accidental overdose with the factor Xa antagonist apixaban in a young child and propose an approach to the management of cases of apixaban overdose in children. Conclusion: Given the increasing use of direct oral anticoagulants, it is important to have an approach to the management of overdose of these medications.

Publication metadata

Author(s): Wiggins M, Biss T, Raffini L, Van Ommen H, Chan A, Vanderpluym C, Goldenberg N, Monagle P

Publication type: Article

Publication status: Published

Journal: Research and Practice in Thrombosis and Haemostasis

Year: 2024

Volume: 8

Issue: 1

Online publication date: 03/01/2024

Acceptance date: 07/12/2023

Date deposited: 20/02/2024

ISSN (electronic): 2475-0379

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.rpth.2023.102312

DOI: 10.1016/j.rpth.2023.102312

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