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Towards a biological diagnosis of PD

Lookup NU author(s): Professor Tiago OuteiroORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

© 2024 The AuthorsSince the original description by James Parkinson, Parkinson's disease (PD) has intrigued us for over 200 years. PD is a progressive condition that is incurable so far, and affects millions of people worldwide. Over the years, our knowledge has expanded tremendously, and a range of criteria have been put forward and used to try to define PD. However, owing to the complexity of the problem, it is still not consensual how to diagnose and classify a disease that manifests with diverse features, and that responds differently to existing therapies and to those under development. We are now living a time when ‘biological’ information is becoming abundant, precise, and accessible enabling us to attempt to incorporate different sources of information to classify different forms of PD. These refinements are essential for basic science, as they will enable us to develop improved models for studying PD, and to implement new findings into clinical practice, as this will be the path towards effective personalized medicine.


Publication metadata

Author(s): Chopra A, Lang AE, Hoglinger G, Outeiro TF

Publication type: Review

Publication status: Published

Journal: Parkinsonism and Related Disorders

Year: 2024

Volume: 122

Print publication date: 01/05/2024

Online publication date: 06/03/2024

Acceptance date: 27/02/2024

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.parkreldis.2024.106078

DOI: 10.1016/j.parkreldis.2024.106078


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