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Lookup NU author(s): Dr David KossORCiD, Professor Tiago OuteiroORCiD
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© 2024 International Society for Neurochemistry.Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor symptoms. Motor symptoms include bradykinesia, resting tremors, muscular rigidity, and postural instability, while non-motor symptoms include cognitive impairments, mood disturbances, sleep disturbances, autonomic dysfunction, and sensory abnormalities. Some of these symptoms may be influenced by the proper hippocampus functioning, including adult neurogenesis. Doublecortin (DCX) is a microtubule-associated protein that plays a pivotal role in the development and differentiation of migrating neurons. This study utilized postmortem human brain tissue of PD and age-matched control individuals to investigate DCX expression in the context of adult hippocampal neurogenesis. Our findings demonstrate a significant reduction in the number of DCX-expressing cells within the subgranular zone (SGZ), as well as a decrease in the nuclear area of these DCX-positive cells in postmortem brain tissue obtained from PD cases, suggesting an impairment in the adult hippocampal neurogenesis. Additionally, we found that the nuclear area of DCX-positive cells correlates with pH levels. In summary, we provide evidence supporting that the process of hippocampal adult neurogenesis is likely to be compromised in PD patients before cognitive dysfunction, shedding light on potential mechanisms contributing to the neuropsychiatric symptoms observed in affected individuals. Understanding these mechanisms may offer novel insights into the pathophysiology of PD and possible therapeutic avenues.
Author(s): Placido E, Koss DJ, Outeiro TF, Brocardo PS
Publication type: Article
Publication status: Published
Journal: Journal of Neurochemistry
Year: 2024
Pages: epub ahead of print
Online publication date: 14/03/2024
Acceptance date: 03/03/2024
ISSN (print): 0022-3042
ISSN (electronic): 1471-4159
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/jnc.16101
DOI: 10.1111/jnc.16101
PubMed id: 38485468
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