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Lookup NU author(s): Dr Jessica Tarn, Dr Dennis LendremORCiD, John CasementORCiD, Professor Fai Ng
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The author(s), published by De Gruyter on behalf of NCRC-DID.In Sjögren’s Syndrome (SS), clinical heterogeneity and discordance between disease activity measures and patient experience are key obstacles to effective therapeutic development. Patient reported outcome measures (PROMs) are useful tools for understanding the unmet needs from the patients’ perspective and therefore they are key for the development of patient centric healthcare systems. Initial concern about the subjectivity of PROMs has given way to methodological rigour and clear guidance for the development of PROMs. To date, several studies of patient stratification using PROMs have identified similar symptom-based subgroups. There is evidence to suggest that these subgroups may represent different disease endotypes with differing responses to therapeutic interventions. Stratified medicine approaches, alongside sensitive outcome measures, have the potential to improve our understanding of SS pathobiology and therapeutic development. The inclusion of PROMs is important for the success of such approaches. In this review we discuss the opportunities of using PROMs in understanding the pathogenesis of and therapeutic development for SS.
Author(s): Berry J, Tarn J, Lendrem D, Casement J, Ng W-F
Publication type: Review
Publication status: Published
Journal: Rheumatology and Immunology Research
Year: 2024
Volume: 5
Issue: 1
Pages: 34-41
Print publication date: 31/03/2024
Online publication date: 31/03/2024
Acceptance date: 04/10/2023
ISSN (electronic): 2719-4523
Publisher: Walter de Gruyter GmbH
URL: https://doi.org/10.1515/rir-2024-0004
DOI: 10.1515/rir-2024-0004
