Toggle Main Menu Toggle Search

Open Access padlockePrints

What can patients tell us in Sjögren’s syndrome?

Lookup NU author(s): Dr Jessica Tarn, Dr Dennis LendremORCiD, John CasementORCiD, Professor Fai Ng

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2024 The author(s), published by De Gruyter on behalf of NCRC-DID.In Sjögren’s Syndrome (SS), clinical heterogeneity and discordance between disease activity measures and patient experience are key obstacles to effective therapeutic development. Patient reported outcome measures (PROMs) are useful tools for understanding the unmet needs from the patients’ perspective and therefore they are key for the development of patient centric healthcare systems. Initial concern about the subjectivity of PROMs has given way to methodological rigour and clear guidance for the development of PROMs. To date, several studies of patient stratification using PROMs have identified similar symptom-based subgroups. There is evidence to suggest that these subgroups may represent different disease endotypes with differing responses to therapeutic interventions. Stratified medicine approaches, alongside sensitive outcome measures, have the potential to improve our understanding of SS pathobiology and therapeutic development. The inclusion of PROMs is important for the success of such approaches. In this review we discuss the opportunities of using PROMs in understanding the pathogenesis of and therapeutic development for SS.


Publication metadata

Author(s): Berry J, Tarn J, Lendrem D, Casement J, Ng W-F

Publication type: Review

Publication status: Published

Journal: Rheumatology and Immunology Research

Year: 2024

Volume: 5

Issue: 1

Pages: 34-41

Print publication date: 31/03/2024

Online publication date: 31/03/2024

Acceptance date: 04/10/2023

ISSN (electronic): 2719-4523

Publisher: Walter de Gruyter GmbH

URL: https://doi.org/10.1515/rir-2024-0004

DOI: 10.1515/rir-2024-0004

Data Access Statement: Not additional data is available.


Share