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Porcine-derived collagen peptides promote re-epithelialisation through activation of integrin signalling

Lookup NU author(s): Dr Krishan Mistry, Grant Richardson, Rob Smith, Professor Penny Lovat



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2024 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society.Chronic non-healing cutaneous wounds represent a major burden to patients and healthcare providers worldwide, emphasising the continued unmet need for credible and efficacious therapeutic approaches for wound healing. We have recently shown the potential for collagen peptides to promote proliferation and migration during cutaneous wound healing. In the present study, we demonstrate that the application of porcine-derived collagen peptides significantly increases keratinocyte and dermal fibroblast expression of integrin α2β1 and activation of an extracellular signal-related kinase (ERK)-focal adhesion kinase (FAK) signalling cascade during wound closure in vitro. SiRNA-mediated knockdown of integrin β1 impaired porcine-derived collagen peptide-induced wound closure and activation of ERK-FAK signalling in keratinocytes but did not impair ERK or FAK signalling in dermal fibroblasts, implying the activation of differing downstream signalling pathways. Studies in ex vivo human 3D skin equivalents subjected to punch biopsy-induced wounding confirmed the ability of porcine-derived collagen peptides to promote wound closure by enhancing re-epithelialisation. Collectively, these data highlight the translational and clinical potential for porcine-derived collagen peptides as a viable therapeutic approach to promote re-epithelialisation of superficial cutaneous wounds.

Publication metadata

Author(s): Mistry K, Richardson G, Vleminckx S, Smith R, Gevaert E, Lovat PE

Publication type: Article

Publication status: Published

Journal: Wound Repair and Regeneration

Year: 2024

Pages: epub ahead of print

Online publication date: 04/04/2024

Acceptance date: 25/03/2024

Date deposited: 17/04/2024

ISSN (print): 1067-1927

ISSN (electronic): 1524-475X

Publisher: John Wiley and Sons Inc


DOI: 10.1111/wrr.13177


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