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Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Lookup NU author(s): Dr Elizaveta Olkhova, Dr Laura Alexandra Smith, Bethany Dennis, Dr Yi NgORCiD, Dr Fiona LeBeauORCiD, Professor Grainne Gorman

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The Author(s). Given the current paucity of effective treatments in many neurological disorders, delineating pathophysiological mechanisms among the major psychiatric and neurodegenerative diseases may fuel the development of novel, potent treatments that target shared pathways. Recent evidence suggests that various pathological processes, including bioenergetic failure in mitochondria, can perturb the function of fast-spiking, parvalbumin-positive neurons (PV+). These inhibitory neurons critically influence local circuit regulation, the generation of neuronal network oscillations and complex brain functioning. Here, we survey PV+ cell vulnerability in the major neuropsychiatric, and neurodegenerative diseases and review associated cellular and molecular pathophysiological alterations purported to underlie disease aetiology.

Publication metadata

Author(s): Olkhova EA, Smith LA, Dennis BH, Ng YS, LeBeau FEN, Gorman GS

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2024

Volume: 52

Issue: 2

Pages: 553-565

Online publication date: 02/04/2024

Acceptance date: 12/03/2024

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

URL: https://doi.org/10.1042/BST20230191

DOI: 10.1042/BST20230191

PubMed id: 38563502

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