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Cardiac development demystified by use of the HDBR atlas

Lookup NU author(s): Professor Bob Anderson, Dr Janet Kerwin, Dr Bill Chaudhry, Dr Steven LisgoORCiD, Professor Deborah HendersonORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2024 The Author(s). Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.Much has been learned over the last half century regarding the molecular and genetic changes that take place during cardiac development. As yet, however, these advances have not been translated into knowledge regarding the marked changes that take place in the anatomical arrangements of the different cardiac components. As such, therefore, many aspects of cardiac development are still described on the basis of speculation rather than evidence. In this review, we show how controversial aspects of development can readily be arbitrated by the interested spectator by taking advantage of the material now gathered together in the Human Developmental Biology Resource; HDBR. We use the material to demonstrate the changes taking place during the formation of the ventricular loop, the expansion of the atrioventricular canal, the incorporation of the systemic venous sinus, the formation of the pulmonary vein, the process of atrial septation, the remodelling of the pharyngeal arches, the major changes occurring during formation of the outflow tract, the closure of the embryonic interventricular communication, and the formation of the ventricular walls. We suggest that access to the resource makes it possible for the interested observer to arbitrate, for themselves, the ongoing controversies that continue to plague the understanding of cardiac development.

Publication metadata

Author(s): Anderson RH, Kerwin J, Lamers WH, Hikspoors JPJM, Mohun TJ, Chaudhry B, Lisgo S, Henderson DJ

Publication type: Review

Publication status: Published

Journal: Journal of Anatomy

Year: 2024

Pages: epub ahead of print

Online publication date: 23/05/2024

Acceptance date: 08/05/2024

ISSN (print): 0021-8782

ISSN (electronic): 1469-7580

Publisher: John Wiley and Sons Inc


DOI: 10.1111/joa.14066