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Lookup NU author(s): Dr Jochem van KempenORCiD, Dr Alwin GieselmannORCiD, Professor Alexander ThieleORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Selective attention is thought to depend on enhanced firing activity in extrastriate areas. Theories suggest that this enhancement depends on selective inter-areal communication via gamma (30–80 Hz) phase-locking. To test this, we simultaneously recorded from different cell types and cortical layers of macaque V1 and V4. We find that while V1-V4 gamma phase-locking between local field potentials increases with attention, the V1 gamma rhythm does not engage V4 excitatory-neurons, but only fast-spiking interneurons in L4 of V4. By contrast, attention enhances V4 spike-rates in both excitatory and inhibitory cells, most strongly in L2/3. The rate increase in L2/3 of V4 precedes V1 in time. These findings suggest enhanced signal transmission with attention does not depend on inter-areal gamma phase-locking and show that the endogenous gamma rhythm has cell-type- and layer-specific effects on downstream target areas. Similar findings were made in the mouse visual system, based on opto-tagging of identified interneurons.
Author(s): Spyropoulos G, Schneider M, van Kempen J, Gieselmann MA, Thiele A, Vinck M
Publication type: Article
Publication status: Published
Journal: Neuron
Year: 2024
Volume: 112
Issue: 14
Pages: 2423-2432.e7
Print publication date: 17/07/2024
Online publication date: 16/05/2024
Acceptance date: 17/04/2024
Date deposited: 11/06/2024
ISSN (print): 0896-6273
ISSN (electronic): 1097-4199
Publisher: Cell Press
URL: https://doi.org/10.1016/j.neuron.2024.04.020
DOI: 10.1016/j.neuron.2024.04.020
Data Access Statement: The data that support the findings of this study are available from the lead contact M.V. Analyses in this study were done in MATLAB and used the FieldTrip toolbox.73 Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
PubMed id: 38759641
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