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Lookup NU author(s): Dr Jochem van KempenORCiD, Dr Alwin GieselmannORCiD, Professor Alexander Thiele
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Selective attention is thought to depend on enhanced firing activity in extrastriate areas. Theories suggest that this enhancement depends on selective inter-areal communication via gamma (30–80 Hz) phase-locking. To test this, we simultaneously recorded from different cell types and cortical layers of macaque V1 and V4. We find that while V1-V4 gamma phase-locking between local field potentials increases with attention, the V1 gamma rhythm does not engage V4 excitatory-neurons, but only fast-spiking interneurons in L4 of V4. By contrast, attention enhances V4 spike-rates in both excitatory and inhibitory cells, most strongly in L2/3. The rate increase in L2/3 of V4 precedes V1 in time. These findings suggest enhanced signal transmission with attention does not depend on inter-areal gamma phase-locking and show that the endogenous gamma rhythm has cell-type- and layer-specific effects on downstream target areas. Similar findings were made in the mouse visual system, based on opto-tagging of identified interneurons.
Author(s): Spyropoulos G, Schneider M, van Kempen J, Gieselmann MA, Thiele A, Vinck M
Publication type: Article
Publication status: Published
Journal: Neuron
Year: 2024
Pages: ePub ahead of Print
Online publication date: 16/05/2024
Acceptance date: 17/04/2024
Date deposited: 11/06/2024
ISSN (print): 0896-6273
ISSN (electronic): 1097-4199
Publisher: Cell Press
URL: https://doi.org/10.1016/j.neuron.2024.04.020
DOI: 10.1016/j.neuron.2024.04.020
PubMed id: 38759641
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