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Lookup NU author(s): Dr Jess Leighton, Professor David Jones, Dr Jess Dyson, Professor Heather Cordell
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024. Primary Sclerosing Cholangitis (PSC) is a progressive cholestatic liver disease with no licensed therapies. Previous Genome Wide Association Studies (GWAS) have identified genes that correlate significantly with PSC, and these were identified by systematic review. Here we use novel Network Proximity Analysis (NPA) methods to identify already licensed candidate drugs that may have an effect on the genetically coded aspects of PSC pathophysiology. Over 2000 agents were identified as significantly linked to genes implicated in PSC by this method. The most significant results include previously researched agents such as metronidazole, as well as biological agents such as basiliximab, abatacept and belatacept. This in silico analysis could potentially serve as a basis for developing novel clinical trials in this rare disease.
Author(s): Leighton J, Jones DEJ, Dyson JK, Cordell HJ
Publication type: Article
Publication status: Published
Journal: BMC Medical Genomics
Year: 2024
Volume: 17
Online publication date: 11/06/2024
Acceptance date: 05/06/2024
Date deposited: 24/06/2024
ISSN (electronic): 1755-8794
Publisher: BioMed Central Ltd
URL: https://doi.org/10.1186/s12920-024-01927-2
DOI: 10.1186/s12920-024-01927-2
PubMed id: 38862968
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