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Lookup NU author(s): Professor Tiago OuteiroORCiD
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© 2024 International Society for Neurochemistry.Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network. The specific molecular drivers of protein aggregation in certain cell types are not well understood, posing tremendous challenges to current research aimed at devising strategies to treat neurodegenerative diseases. This preface introduces the special issue “Aging and Neurodegeneration: from molecular mechanisms to therapeutic interventions,” featuring articles that assess the drivers of pathology in the aging cell, including oxidative stress, protein glycation/aggregation, and mitochondrial impairment.
Author(s): Outeiro TF, Brocardo PS, Gelain DP
Publication type: Editorial
Publication status: Published
Journal: Journal of Neurochemistry
Year: 2024
Volume: 168
Issue: 8
Pages: 1423-1425
Print publication date: 01/08/2024
Online publication date: 22/06/2024
Acceptance date: 12/06/2024
ISSN (print): 0022-3042
ISSN (electronic): 1471-4159
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/jnc.16163
DOI: 10.1111/jnc.16163