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Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

© 2024 International Society for Neurochemistry.Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network. The specific molecular drivers of protein aggregation in certain cell types are not well understood, posing tremendous challenges to current research aimed at devising strategies to treat neurodegenerative diseases. This preface introduces the special issue “Aging and Neurodegeneration: from molecular mechanisms to therapeutic interventions,” featuring articles that assess the drivers of pathology in the aging cell, including oxidative stress, protein glycation/aggregation, and mitochondrial impairment.

Publication metadata

Author(s): Outeiro TF, Brocardo PS, Gelain DP

Publication type: Editorial

Publication status: Published

Journal: Journal of Neurochemistry

Year: 2024

Pages: epub ahead of print

Online publication date: 22/06/2024

Acceptance date: 12/06/2024

ISSN (print): 0022-3042

ISSN (electronic): 1471-4159

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1111/jnc.16163

DOI: 10.1111/jnc.16163

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