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Lookup NU author(s): Sarah Rae, Ellie Taylor, Joseph Hoben, Dr Christoph OingORCiD, Professor Alastair GreystokeORCiD, Professor Ruth Plummer
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024.Background: Early phase clinical trials in Oncology represent a subspecialised area where UK patient selection is influenced by access to Experimental Cancer Medicine Centres (ECMCs). Equity of access with respect to social determinants of health (SDoH) were explored for two major ECMCs. Methods: A retrospective cohort study including all referrals to Newcastle and Manchester ECMCs in 2021 was completed. Consent to screening or pre-screening was stratified against SDoH characteristics, including: Index of Multiple Deprivation (IMD) decile, ethnicity and distance to centre. Results: 1243 patients were referred for trials. IMD quintile 1 (most deprived) patients had reduced likelihood of referral compared to expected population models (OR, 0.67; 95% CI: 0.55 to 0.80, p = <0.0001). IMD quintile 5 (least deprived) had increased likelihood of referral (OR, 1.46; 95% CI: 1.17 to 1.82, p = 0.0007). Living beyond median distance from Manchester reduced the likelihood of consenting to trials (OR, 0.72; 95% CI: 0.55 to 0.94, p = 0.015). Ethnicity data represented a White British propensity. Conclusions: Inequalities in socioeconomic and geographic factors influence referral and enrolment to early phase clinical trials in Northern England. This has implications for equity of access and generalisability of trial results internationally and warrants further study.
Author(s): Rae S, Shaya S, Taylor E, Hoben J, Oluwashegun D, Lowe H, Haris N, Bashir S, Oing C, Krebs MG, Thistlethwaite FC, Carter L, Cook N, Greystoke A, Graham DM, Plummer R
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Year: 2024
Pages: epub ahead of print
Online publication date: 24/06/2024
Acceptance date: 13/06/2024
Date deposited: 05/07/2024
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41416-024-02765-w
DOI: 10.1038/s41416-024-02765-w
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