Dr Lisa Crowe Dr Morven Brown Dr Jan Lecouturier Professor Alastair Greystoke Professor Linda Sharp et al. | “Oh when’s your treatment ending?” “Never!” The unmet needs of cancer patients treated with immuno-, biological and precision therapies: a qualitative interview study | 2024 |
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Professor Alastair Greystoke
| A phase Ib study evaluating the recommended phase II dose, safety, tolerability, and efficacy of mivavotinib in combination with nivolumab in advanced solid tumors | 2024 |
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Professor Alastair Greystoke Professor Ruth Plummer Dr Christoph Oing Dr Pasquale Rescigno
| Combining PARP Inhibitors and Androgen Receptor Signalling Inhibitors in Metastatic Prostate Cancer: A Quantitative Synthesis and Meta-analysis | 2024 |
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Professor Alastair Greystoke
| First-line Avelumab plus Chemotherapy in Patients with Advanced Solid Tumors: Results from the Phase Ib/II JAVELIN Chemotherapy Medley Study | 2024 |
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Dr Abi Gault Dr Linda Hogarth Dr Kristian Williams Professor Alastair Greystoke Professor Neil Rajan et al. | Monitoring immunE DysregulAtion foLLowing Immune checkpOint-inhibitioN (MEDALLION): protocol for an observational cancer immunotherapy cohort study | 2024 |
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Professor Alastair Greystoke
| Results From First-in-Human Phase I Dose-Escalation Study of a Novel Bicycle Toxin Conjugate Targeting EphA2 (BT5528) in Patients With Advanced Solid Tumors | 2024 |
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Sarah Rae Ellie Taylor Joseph Hoben Dr Christoph Oing Professor Alastair Greystoke et al. | Social determinants of health inequalities in early phase clinical trials in Northern England | 2024 |
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Dr Ruth Norris Dr Rosie Dew Professor Alastair Greystoke Dr Nicola Cresti Henry Cain et al. | Socio-demographic disparities in HER2+ breast cancer trastuzumab receipt: An English population-based study | 2024 |
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Professor Gareth Veal Professor Steve Wedge Dr Christopher Bacon Professor Philip Sloan Professor Alastair Greystoke et al. | A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer | 2023 |
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Dr Lisa Crowe Dr Morven Brown Professor Alastair Greystoke Jan Lecouturier Professor Adam Todd et al. | Assessing the unmet needs of patients with advanced cancer treated by biological and precision therapies: protocol for TARGET, a mixed methods study | 2023 |
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Dr Ruth Norris Dr Liz Fuller Professor Alastair Greystoke Professor Adam Todd Professor Linda Sharp et al. | OP41 Routes to diagnosis in lung cancer – do socio-demographics matter? An English population-based study | 2023 |
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Dr Ruth Norris Professor Alastair Greystoke Professor Adam Todd Professor Linda Sharp
| OP42 Socio-economic inequalities in novel NSCLC treatments during the era of tumour biomarker guided therapy: a population-based cohort study | 2023 |
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Sarah Rae Dr Linda Hogarth Alison Bridgewood Lisa Brown-Schofield Dr Saira Bashir et al. | Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders | 2023 |
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Dr Ruth Norris Dr Rosie Dew Professor Alastair Greystoke Professor Adam Todd Professor Linda Sharp et al. | Socio-economic Inequalities in Novel NSCLC Treatments During the Era of Tumor Biomarker Guided Therapy: A Population-based Cohort Study in a Publicly Funded Healthcare System | 2023 |
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Jakub Chmelo Professor Alexander Phillips Professor Alastair Greystoke Dr Sarah Charman Dr Leah Avery et al. | A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study | 2022 |
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Dr Matthew Cooper Jakub Chmelo Dr Rhona Sinclair Dr Sarah Charman Dr Kate Hallsworth et al. | Exploring factors influencing uptake and adherence to a home-based prehabilitation physical activity and exercise intervention for patients undergoing chemotherapy before major surgery (ChemoFit): a qualitative study | 2022 |
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Professor Alastair Greystoke
| Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations-CONCORDE | 2022 |
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Dr Ruth Norris Professor Adam Todd Professor Alastair Greystoke Professor Linda Sharp
| OA01.05 Socio-economic Inequalities in NSCLC Treatment During the Era of Tumour Biomarker Guided Therapy: A Population-based Study | 2022 |
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Professor Alastair Greystoke
| Targeting CD38 and PD-1 with isatuximab plus cemiplimab in patients with advanced solid malignancies: results from a phase I/II open-label, multicenter study | 2022 |
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Jenny Welford Kathryn Hunt Louise Duncan Dr Ann Ward Professor Adam Todd et al. | The Clinical Frailty Scale can indicate prognosis and care requirements on discharge in oncology and haemato-oncology inpatients: A cohort study. | 2022 |
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Jakub Chmelo Professor Alexander Phillips Professor Alastair Greystoke Dr Alex Bradshaw Dr Rhona Sinclair et al. | Comparison of the effects of FLOT and ECX chemotherapy for oesophagogastric adenocarcinoma on cardiopulmonary reserve | 2021 |
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Professor Alastair Greystoke
| Randomised controlled trial of intermittent vs continuous energy restriction during chemotherapy for early breast cancer | 2021 |
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Jakub Chmelo Professor Alexander Phillips Professor Alastair Greystoke Dr Sarah Charman Dr Leah Avery et al. | A feasibility study to investigate the utility of a home-based exercise intervention during and after neo-adjuvant chemotherapy for oesophago-gastric cancer-the ChemoFit study protocol | 2020 |
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Ruth Norris Dr Rosie Dew Professor Linda Sharp Professor Alastair Greystoke Dr Sarah Rice et al. | Are there socio-economic inequalities in utilization of predictive biomarker tests and biological and precision therapies for cancer? A systematic review and meta-analysis | 2020 |
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Dr Nicola Hannaway Professor Alastair Greystoke
| CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer | 2020 |
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Dr Eleanor Smith Professor Alastair Greystoke
| The care of older cancer patients in the United Kingdom | 2020 |
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Professor Alastair Greystoke
| The National Lung Matrix Trial of personalised therapy in lung cancer | 2020 |
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Professor Alastair Greystoke
| 105O - Osimertinib for patients (pts) with leptomeningeal metastases (LM) associated with EGFRm advanced NSCLC: The AURA LM study | 2019 |
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Professor Alastair Greystoke
| 140P - Brigatinib experience on the ALK project | 2019 |
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Professor Ruth Plummer Professor Alastair Greystoke
| A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours | 2019 |
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Alice Coomer Dr Fiona Black Professor Alastair Greystoke Dr Jennifer Munkley Professor David Elliott et al. | Alternative splicing in lung cancer | 2019 |
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Professor Alastair Greystoke
| Implications for UK practice of the use of durvalumab in stage III NSCLC | 2019 |
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Professor Alastair Greystoke
| Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomalformulation in patients with solid tumours | 2019 |
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Dr Maziar Navidi Professor Alexander Phillips Professor Michael Griffin Professor Alastair Greystoke Dr Kate Sumpter et al. | Cardiopulmonary fitness before and after neoadjuvant chemotherapy in patients with oesophagogastric cancer | 2018 |
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Dr Joanna Perthen Dr Tamir Ali David McCulloch Maziar Navidi Professor Alexander Phillips et al. | Intra- and Interobserver Variability in Skeletal Muscle Measurements using Computed Tomography Images | 2018 |
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Professor Alastair Greystoke
| ASCEND-8: A Randomized Phase 1 Study of Ceritinib, 450 mg or 600 mg, Taken with a Low-Fat Meal versus 750 mg in Fasted State in Patients with Anaplastic Lymphoma Kinase (ALK)-Rearranged Metastatic Non–Small Cell Lung Cancer (NSCLC) | 2017 |
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Professor Alastair Greystoke Dr Noor MD Haris Professor Ruth Plummer
| SELECT-3: A phase i study of selumetinib in combination with platinum-doublet chemotherapy for advanced NSCLC in the first-line setting | 2017 |
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Dr David Jamieson Melanie Griffin Julieann Sludden Dr Yvette Drew Dr Nicola Cresti et al. | A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours | 2016 |
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Dr Nicola Wyatt Dr Linda Hogarth Dianne Turner Dr Miranda Patterson Dr David Jamieson et al. | Circulating Biomarkers of Frailty Are Associated with a Poor Prognosis in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) | 2016 |
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Dr Sally Hall Professor Alastair Greystoke Dr Christopher Jones Dr Jane Margetts
| Crizotinib in clinical practice: the North East of England's experience | 2016 |
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Professor Alastair Greystoke
| Development of a circulating miRNA assay to monitor tumor burden: From mouse to man | 2016 |
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Professor Ruth Plummer Professor Alastair Greystoke
| SELECT-3: A phase I study of selumetinib in combination with platinum doublet chemotherapy for advanced NSCLC in the first-line setting | 2016 |
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Professor Alastair Greystoke Dr Linda Hogarth Dr Miranda Patterson Liam Bolt Dianne Turner et al. | The introduction of the Cancer Research UK Stratified Medicine Programme 2 (CRUK SMP2) in North East England; lessons learned and experience gained | 2016 |
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Dr Yvette Drew Professor Alastair Greystoke Professor Ruth Plummer
| A first-in-human dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of oral 2-hydroxyoleic acid (2-OHOA) in adult patients (pt) with advanced solid tumors including grade III/IV glioblastoma multiforme (GBM). | 2015 |
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Professor Ruth Plummer Professor Alastair Greystoke
| A phase Ib dose-escalation study of GSK2256098 (FAKi) plus trametinib (MEKi) in patients with selected advanced solid tumors | 2015 |
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Professor Alastair Greystoke
| An Introduction to Stratified Medicine | 2015 |
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Professor Alastair Greystoke
| First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014 | 2015 |
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Professor Vinidh Paleri Professor Alastair Greystoke Dr Charles Kelly
| Spindle cell carcinoma of the head and neck region: Treatment and outcomes of 15 patients | 2015 |
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Dr Manolo D'Arcangelo Dr Jane Margetts Professor Alastair Greystoke
| The use of circulating biomarkers in early clinical trials in patients with cancer | 2015 |
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Professor Alastair Greystoke
| A Phase I, Dose-Escalation Study of the Multitargeted Receptor Tyrosine Kinase Inhibitor, Golvatinib, in Patients with Advanced Solid Tumors | 2014 |
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Professor Alastair Greystoke
| Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer | 2014 |
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Professor Alastair Greystoke
| A study to investigate dose escalation of doxorubicin in ABVD chemotherapy for Hodgkin lymphoma incorporating biomarkers of response and toxicity | 2013 |
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Professor Alastair Greystoke
| Assessment of diurnal changes and confounding factors that affect circulating cell death biomarker levels: A short communication | 2013 |
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Professor Alastair Greystoke
| A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients | 2012 |
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Professor Alastair Greystoke
| Biomarkers of cell death applicable to early clinical trials | 2012 |
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Professor Alastair Greystoke
| Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung Cancer | 2012 |
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Professor Alastair Greystoke
| How Many Diseases Are Colorectal Cancer? | 2012 |
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Professor Alastair Greystoke
| Learning from toxicity patterns in phase I trials during the era of mechanism targeted agents | 2012 |
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Professor Alastair Greystoke
| Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer | 2012 |
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Mark Leslie Julieann Sludden Professor Ruth Plummer Professor Alastair Greystoke Professor Alan Calvert et al. | A phase I and pharmacodynamic study of a 7 day infusion schedule of the DNMT1 antisense compound MG98. | 2005 |
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