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Lookup NU author(s): Dr Annette Meeson, Dr Rachel Oldershaw, Professor Gavin RichardsonORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
This study investigates the characteristics of cardiac mesenchymal stem cell-like cells (CMSCLCs) isolated from the right atrial appendage of human donors with ischemia and a young patient with endocarditis (NE-CMSCLCs). Typical CMSCLCs from ischemic heart patients were derived from coronary artery bypass grafting procedures, and compared against bone marrow mesenchymal stromal cells (BM-MSCs). NE-CMSCLCs had a normal immunophenotype but exhibited enhanced osteogenic differentiation potential, rapid proliferation, reduced senescence, reduced glycolysis, and lower reactive oxygen species generation after oxidative stress compared to typical ischemic CMSCLCs. These differences suggest a unique functional status of NE-CMSCLCs, influenced by the donor health condition. Despite large variances in their paracrine secretome, NE-CMSCLCs retained therapeutic potential, as indicated by their ability to protect hypoxia/reoxygenation-injured human cardiomyocytes, albeit less effectively than typical CMSCLCs. This research describes a unique cell phenotype and underscores the importance of donor health status in the therapeutic efficacy of autologous cardiac cell therapy.
Author(s): Nguyen H, Hsu C, Meeson A, Oldershaw RA, Richardson GD, Czosseck A, Lundy D
Publication type: Article
Publication status: Published
Journal: Stem Cells and Development
Year: 2024
Pages: epub ahead of print
Online publication date: 28/06/2024
Acceptance date: 14/06/2024
Date deposited: 02/07/2024
ISSN (print): 1547-3287
ISSN (electronic): 1557-8534
Publisher: Mary Ann Liebert, Inc. Publishers
URL: https://doi.org/10.1089/scd.2024.0103
DOI: 10.1089/scd.2024.0103
ePrints DOI: 10.57711/txdb-tm73
Data Access Statement: All data are contained in the manuscript.
PubMed id: 38940748
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