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Lookup NU author(s): Anthony McLean, Dr Gary Reynolds, Dr Arthur PrattORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 by the authors. The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis, and skin psoriasis, albeit only for subsets of individuals with each condition. This suggests intersecting “nodes” in inflammatory networks at a molecular and cellular level may drive and/or maintain IMIDs, being “shared” between traditionally distinct diagnoses without mapping neatly to a single clinical phenotype. In line with this proposition, integrative tumour tissue analyses in oncology have highlighted novel cell states acting across diverse cancers, with important implications for precision medicine. Drawing upon advances in the oncology field, this narrative review will first summarise learnings from the Human Cell Atlas in health as a platform for interrogating IMID tissues. It will then review cross-disease studies to date that inform this endeavour before considering future directions in the field.
Author(s): McLean AK, Reynolds G, Pratt AG
Publication type: Review
Publication status: Published
Journal: Biomedicines
Year: 2024
Volume: 12
Issue: 6
Online publication date: 12/06/2024
Acceptance date: 08/06/2024
ISSN (electronic): 2227-9059
Publisher: MDPI
URL: https://doi.org/10.3390/biomedicines12061297
DOI: 10.3390/biomedicines12061297
