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Lookup NU author(s): Dr Bilal Bawamia, Muntaser Omari, Professor Ioakim SpyridopoulosORCiD, Dr Mohammad Alkhalil
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© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Eosinophils are recruited to the heart during acute myocardial infarction (MI) and are considered part of the inflammatory response associated with adverse clinical outcomes. We assessed the impact of eosinopenia on cardiac imaging biomarkers in patients presenting with ST-segment elevation MI. This is a post-hoc analysis of the Evaluating the effectiveness of intravenous Ciclosporin on reducing reperfusion injury in pAtients undergoing PRImary percutaneous coronary intervention (CAPRI) trial. Patients underwent cardiac MRI within 1 week and 12 weeks and low eosinophil was defined as less than 40 cells/ml. The study included 52 patients and 38% had low eosinophil. Ciclosporin administration was comparable between patients with low versus normal eosinophils. The ischaemia time was significantly longer in low eosinophil patients [262 (205–325) vs. 138 (102–195) minutes, P < 0.001]. At 12 weeks, patients with eosinopenia had larger infarct size [9.8% (5.7–18.4) vs. 7.4% (1.9–10.2), P = 0.045], larger left ventricle (LV) end systolic volume (89 ± 28 vs. 68 ± 23, P = 0.02), and lower LV ejection fraction (EF) (49 ± 9 vs. 58 ± 7, P < 0.001). After adjustments for significant predictors, including ischaemia time, low eosinophil count was an independent predictor of worse LVEF at 12 weeks [-5.78, 95% CI (-11.22 to -0.34), P = 0.038] but not infarct size [1.83, 95% CI (-2.77 to 6.43), P = 0.43]. Patients with low eosinophil count had larger infarct size and LV volumes and worse adverse remodeling compared to those with normal eosinophil count. At 12 weeks, eosinopenia was an independent predictor of worse LVEF but not infarct size.
Author(s): Bawamia B, Gupta A, Omari M, Farag M, Spyridopoulos I, Alkhalil M
Publication type: Article
Publication status: Published
Journal: Journal of Thrombosis and Thrombolysis
Year: 2024
Pages: ePub ahead of Print
Online publication date: 21/09/2024
Acceptance date: 04/09/2024
ISSN (print): 0929-5305
ISSN (electronic): 1573-742X
Publisher: Springer Nature
URL: https://doi.org/10.1007/s11239-024-03042-6
DOI: 10.1007/s11239-024-03042-6
PubMed id: 39306654
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