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Lookup NU author(s): Professor Tiago OuteiroORCiD
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© 2024 Elsevier B.V. We previously demonstrated that JM-20, a molecule with neuroactive functions, protects rats against rotenone and 6-hydroxydopamine (6-OHDA) neurotoxicity. In addition, we demonstrated that JM-20 inhibits the aggregation and cytotoxicity of alpha-synuclein in vitro. In this study, we performed correlation studies between morphological and molecular variables, as well as the motor behavior of parkinsonian rats (6-OHDA and rotenone lesion) treated with JM-20 at different doses (oral with gavage). Our results showed that higher asymmetry evaluated in the cylinder test correlated with greater redox alterations, death of dopaminergic neurons and increased astrogliosis. In the rotenone model, our results showed that a lower number of vertical rearing was correlated with greater redox alterations and increased mitochondrial dysfunction. In both models (6-OHDA and rotenone), parkinsonian animals treated with the highest doses of JM-20 (20 and 40 mg/kg) showed reduced behavioral impairments (lower asymmetry value and higher amount of vertical rearing). Also, a reduced loss of mesencephalic dopaminergic neurons, a smaller number of astrocyte cells in this region, less redox alterations and less mitochondrial dysfunction was observed. In total, our results demonstrate a correlation between behavioral and biochemical variables evaluated in the preclinical models of parkinsonism induced by 6-OHDA and rotenone.
Author(s): Fonseca-Fonseca LA, Fuentes NP, Sanchez JR, Iglesias AT, Outeiro TF, Silva VDAD, Costa SL, Nunez-Figueredo Y
Publication type: Article
Publication status: Published
Journal: Behavioural Brain Research
Year: 2025
Volume: 476
Print publication date: 05/01/2025
Online publication date: 21/09/2024
Acceptance date: 20/09/2024
ISSN (print): 0166-4328
ISSN (electronic): 1872-7549
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.bbr.2024.115269
DOI: 10.1016/j.bbr.2024.115269
PubMed id: 39313072
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