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Lookup NU author(s): Dr Fiona LeBeauORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s). Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of The New York Academy of Sciences.Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age-related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage-gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL/6J mice to explore age-related alterations in their voltage-gated ionic currents (n > 30 patches, eight mice in each group). We observed that the voltage-gated inward sodium current (peak INa(Max)) was significantly decreased with aging in the SG, but not in the ventricle. Additionally, Scn8a gene expression, which encodes the Nav 1.6 channel, was decreased with aging in the SG. Application of loose patch clamp electrophysiology thus suggests that ionic current alterations with age in murine SG could contribute to cardiac autonomic dysregulation in geriatric conditions.
Author(s): Lee B, Ahmad S, Edling CE, Huang CLH, LeBeau FEN, Jeevaratnam K
Publication type: Article
Publication status: Published
Journal: Annals of the New York Academy of Sciences
Year: 2025
Volume: 1545
Issue: 1
Pages: 91-104
Print publication date: 01/03/2025
Online publication date: 25/02/2025
Acceptance date: 02/04/2018
Date deposited: 17/03/2025
ISSN (print): 0077-8923
ISSN (electronic): 1749-6632
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/nyas.15298
DOI: 10.1111/nyas.15298
Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request
PubMed id: 39998310
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