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Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events

Lookup NU author(s): Professor Miles WithamORCiD, Dr David McAllister

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Wightman H, Butterly E, Wei L, McChystal R, Sattar N, Adler A, Phillippo D, Dias S, Welton N, Clegg A, Witham M, Rockwood K, McAllister DA, Hanlon P

Publication type: Article

Publication status: Published

Journal: PLoS Medicine

Year: 2025

Volume: 22

Issue: 4

Online publication date: 07/04/2025

Acceptance date: 11/03/2025

Date deposited: 17/03/2025

ISSN (electronic): 1549-1676

Publisher: Public Library of Science

URL: https://doi.org/10.1371/journal.pmed.1004553

DOI: 10.1371/journal.pmed.1004553

Data Access Statement: This study used individual participant data from industry-sponsored randomized controlled trials. The trial data are available upon application to the trial sponsors via the Vivli analysis platform (https://search.vivli.org/) subject to a data sharing agreement. This data sharing agreement stipulates that all individual-level data are held securely within a remote analysis platform. All model outputs from our analyses, and aggregated data and summarized statistics are included within the supplementary appendix, along with analysis code on which all of the presented results are based (S2 Appendix).


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Funding

Funder referenceFunder name
MR/T017112/1
MRC
Tenovus Scotland

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