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Lookup NU author(s): Professor Johannes AttemsORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s). Advanced Biology published by Wiley-VCH GmbH.Aging is a progressive and irreversible process, serving as the primary risk factor for neurodegenerative disorders. This study aims to identify the molecular mechanisms underlying physiological aging within the substantia nigra, which is primarily affected by Parkinson's disease, and to draw potential conclusions on the earliest events leading to neurodegeneration in this specific brain region. The characterization of essential stages in aging progress can enhance knowledge of the mechanisms that promote the development of Parkinson's disease. To gain a comprehensive overview three study groups are utilized: young individuals (mean age: 28.7 years), middle-aged (mean age: 62.3 years), and elderly individuals (mean age: 83.9 years). Using the proteomic approach, crucial features of physiological aging are able to be identified. These include heightened oxidative stress, enhanced lysosomal degradation, autophagy, remodeling of the cytoskeleton, changes in the structure of the mitochondria, alterations in vesicle transportation, and synaptic plasticity.
Author(s): Eggers B, Steinbach S, Aldea IG, Keers S, Molina M, Grinberg LT, Heinsen H, Paraizo Leite RE, Attems J, May C, Marcus K
Publication type: Article
Publication status: Published
Journal: Advanced Biology
Year: 2025
Online publication date: 12/03/2025
Acceptance date: 17/12/2024
Date deposited: 15/04/2025
ISSN (electronic): 2701-0198
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/adbi.202400814
DOI: 10.1002/adbi.202400814
Data Access Statement: The data that support the findings of this study are openly available in Pro- teomeXChange at https://proteomecentral.proteomexchange.org/ui, reference number 51145.
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