Browse by author
Lookup NU author(s): Dr Connor Richardson, Professor Adam ToddORCiD, Professor Fiona MatthewsORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
BackgroundEvidence from epidemiological and clinical studies of the effect of anti-inflammatory medication on dementia risk has been mixed. Over the past two decades there has been recurring epidemiological evidence that the use of NSAID’s for chronic inflammatory conditions is associated with a lower incidence of dementia.MethodCognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989-1994). Three areas (CFAS I) were selected for new sampling two decades later (2008-2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Data on medication use and dementia status was assessed at each wave.ResultLow dose aspirin (< 150 mg) use was associated by a reduction in dementia incidence rate (IR) in women from 60.99 (95% CI: 47.6, 78.2) per 1000 person-years to 44.1 (95% CI: 2.0, 45.4) in 1993 and from 44.5 (33.7, 58.7) to 38.6 (27.2, 54.9) in 2013. No reduction in men was found.ConclusionThis study shows evidence that routine use of low-dose aspirin reduces population risk of dementia in women. Mixed results in men show further analysis is needed to asses the effect over a longer follow-up with a broader range of anti-inflammatory medication.
Author(s): Richardson CD, Todd A, Matthews FE
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Alzheimer’s Association International Conference AAIC 2024
Year of Conference: 2024
Pages: e092406
Print publication date: 01/12/2024
Online publication date: 09/01/2025
Acceptance date: 02/04/2024
Date deposited: 22/05/2025
ISSN: 1552-5260
Publisher: John Wiley & Sons, Inc.
URL: https://doi.org/10.1002/alz.092406
DOI: 10.1002/alz.092406
PubMed id: 11715312
Series Title: Alzheimer’s & Dementia
