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Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Lookup NU author(s): Jessie Nie, Dr Jim StewartORCiD, Professor Patrick Chinnery

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

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Author(s): Frison M, Lockey BS, Nie Y, Golder Z, Theiaspra E, Ryall CD, Lyons C, Burr SP, Prater M, Bozhilova LV, Glynos A, Stewart JB, Jones NS, Chiaratti MR, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Science

Year: 2025

Volume: 390

Issue: 6769

Pages: 156-163

Print publication date: 09/10/2025

Acceptance date: 17/07/2025

Date deposited: 10/10/2025

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science (AAAS)

URL: https://doi.org/10.1126/science.adr5438

DOI: 10.1126/science.adr5438

ePrints DOI: 10.57711/080e-9023

Data Access Statement: All materials generated in this study are readily available from the authors. All data are available in the manuscript, in the supplementary materials, or at Zenodo (https://zenodo.org/records/15878759). The m.5024C>T mouse line is available from J.B.S. under a material agreement with the Max Planck Institute for Biology of Aging.

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