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Browsing publications by Dr Jim Stewart.

Newcastle AuthorsTitleYearFull text
Dr Jim Stewart
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function2022
Dr Jim Stewart
A Mitochondrial Targeted Meganuclease Eliminates Mutant Mitochondrial DNA in a Mouse Model2021
Dr Jim Stewart
Chapter 10: High throughput detection of mtDNA mutations leading to tRNA processing errors2021
Dr Jim Stewart
Current Progress with Mammalian Models of Mitochondrial DNA Disease2021
Dr Jim Stewart
Professor Patrick Chinnery
Extreme heterogeneity of human mitochondrial DNA from organelles to populations2021
Dr Jim Stewart
Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission2021
Dr Jim Stewart
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing2020
Dr Jim Stewart
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse2019
Dr Laura Greaves
Professor Robert Taylor
Dr Jim Stewart
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency2018
Dr Jim Stewart
Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice2018
Dr Jim Stewart
Delivery of mtZFNs into Early Mouse Embryos2018
Dr Jim Stewart
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo2018
Dr Thomas Nicholls
Dr Jim Stewart
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria2018
Dr Jim Stewart
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation2018
Dr Jim Stewart
Increased total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load2017
Holly Baines
Dr Craig Stamp
Dr Laura Greaves
Dr Jim Stewart
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease2016
Dr Jim Stewart
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly2016
Dr Jim Stewart
Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division2016
Dr Jim Stewart
Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies2015
Dr Jim Stewart
Mitochondrial DNA: Radically free of free-radical driven mutations2015
Dr Jim Stewart
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers2015
Dr Jim Stewart
Professor Patrick Chinnery
The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease2015
Dr Jim Stewart
The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication2015
Dr Jim Stewart
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age2014
Dr Jim Stewart
Keeping mtDNA in shape between generations2014
Dr Jim Stewart
No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline2014
Holly Baines
Dr Jim Stewart
Craig Stamp
Dr Anze Zupanic
Emeritus Professor Thomas Kirkwood
et al.
Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans2014
Professor Patrick Chinnery
Dr Lyndsey Butterworth
Dr Jim Stewart
Professor Mary Herbert
Emeritus Professor Doug Turnbull
et al.
The Challenges of Mitochondrial Replacement2014
Christoph Freyer
Dr Lynsey Cree
Dr Jim Stewart
Dr Vasileios Floros
Dr David Samuels
et al.
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission2012
Dr Jim Stewart
Dr Joanna Elson
Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease2008