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Browsing publications by
Dr Jim Stewart.
Newcastle Authors
Title
Year
Full text
Dr Tiago Gomes Bernardino Gomes
Dr Amy Vincent
Dr Katja Menger
Dr Jim Stewart
Dr Thomas Nicholls
et al.
Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation
2024
Dr Jim Stewart
mitoTALEN Eliminates Mutant mtDNA Genomes in Neurons
2024
Dr Jim Stewart
Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation
2024
Dr Jim Stewart
Professor Patrick Chinnery
Cell lineage-specific mitochondrial resilience during mammalian organogenesis
2023
Dr Jim Stewart
Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine
2023
Dr Jim Stewart
Professor Patrick Chinnery
High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life
2023
Dr Jim Stewart
Large dataset of octocoral mitochondrial genomes provides new insights into
mt-mutS
evolution and function
2022
Dr Jim Stewart
The [PSI+] prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of
COX12
2022
Dr Jim Stewart
A Mitochondrial Targeted Meganuclease Eliminates Mutant Mitochondrial DNA in a Mouse Model
2021
Dr Jim Stewart
Current Progress with Mammalian Models of Mitochondrial DNA Disease
2021
Dr Jim Stewart
Professor Patrick Chinnery
Extreme heterogeneity of human mitochondrial DNA from organelles to populations
2021
Dr Jim Stewart
High throughput detection of mtDNA mutations leading to tRNA processing errors
2021
Dr Jim Stewart
Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission
2021
Dr Jim Stewart
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing
2020
Dr Jim Stewart
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
2019
Professor Laura Greaves
Professor Robert Taylor
Dr Jim Stewart
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency
2018
Dr Jim Stewart
Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice
2018
Dr Jim Stewart
Delivery of mtZFNs into Early Mouse Embryos
2018
Dr Jim Stewart
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
2018
Dr Thomas Nicholls
Dr Jim Stewart
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
2018
Dr Jim Stewart
MitoTALEN reduces mutant mtDNA load and restores tRNA
Ala
levels in a mouse model of heteroplasmic mtDNA mutation
2018
Dr Jim Stewart
Increased total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load
2017
Holly Baines
Dr Craig Stamp
Professor Laura Greaves
Dr Jim Stewart
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
2016
Dr Jim Stewart
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly
2016
Dr Jim Stewart
Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division
2016
Dr Jim Stewart
Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
2015
Dr Jim Stewart
Mitochondrial DNA: Radically free of free-radical driven mutations
2015
Dr Jim Stewart
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers
2015
Dr Jim Stewart
Professor Patrick Chinnery
The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease
2015
Dr Jim Stewart
The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
2015
Dr Jim Stewart
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
2014
Dr Jim Stewart
Keeping mtDNA in shape between generations
2014
Dr Jim Stewart
No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline
2014
Holly Baines
Dr Jim Stewart
Craig Stamp
Dr Anze Zupanic
Emeritus Professor Thomas Kirkwood
et al.
Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
2014
Professor Patrick Chinnery
Dr Lyndsey Butterworth
Dr Jim Stewart
Professor Mary Herbert
Emeritus Professor Doug Turnbull
et al.
The Challenges of Mitochondrial Replacement
2014
Christoph Freyer
Dr Lynsey Cree
Dr Jim Stewart
Dr Vasileios Floros
Dr David Samuels
et al.
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
2012
Dr Jim Stewart
Dr Joanna Elson
Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease
2008