Dr Jim Stewart
| Correcting a pathogenic mitochondrial DNA mutation by base editing in mice | 2025 |
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Dr Tiago Gomes Bernardino Gomes
Dr Amy Vincent
Dr Katja Menger
Dr Jim Stewart
Dr Thomas Nicholls
et al. | Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation | 2024 |
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Dr Jim Stewart
| mitoTALEN Eliminates Mutant mtDNA Genomes in Neurons | 2024 |
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Dr Jim Stewart
| Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation | 2024 |
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Dr Jim Stewart
Professor Patrick Chinnery
| Cell lineage-specific mitochondrial resilience during mammalian organogenesis | 2023 |
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Dr Jim Stewart
| Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine | 2023 |
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Dr Jim Stewart
Professor Patrick Chinnery
| High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life | 2023 |
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Dr Jim Stewart
| Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function | 2022 |
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Dr Jim Stewart
| The [PSI+] prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12 | 2022 |
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Dr Jim Stewart
| A Mitochondrial Targeted Meganuclease Eliminates Mutant Mitochondrial DNA in a Mouse Model | 2021 |
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Dr Jim Stewart
| Current Progress with Mammalian Models of Mitochondrial DNA Disease | 2021 |
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Dr Jim Stewart
Professor Patrick Chinnery
| Extreme heterogeneity of human mitochondrial DNA from organelles to populations | 2021 |
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Dr Jim Stewart
| High throughput detection of mtDNA mutations leading to tRNA processing errors | 2021 |
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Dr Jim Stewart
| Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission | 2021 |
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Dr Jim Stewart
| Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing | 2020 |
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Dr Jim Stewart
| Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse | 2019 |
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Professor Laura Greaves
Professor Robert Taylor
Dr Jim Stewart
| A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency | 2018 |
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Dr Jim Stewart
| Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice | 2018 |
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Dr Jim Stewart
| Delivery of mtZFNs into Early Mouse Embryos | 2018 |
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Dr Jim Stewart
| Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo | 2018 |
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Dr Thomas Nicholls
Dr Jim Stewart
| Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria | 2018 |
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Dr Jim Stewart
| MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation | 2018 |
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Dr Jim Stewart
| Increased total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load | 2017 |
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Holly Baines
Dr Craig Stamp
Professor Laura Greaves
Dr Jim Stewart
| A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease | 2016 |
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Dr Jim Stewart
| Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly | 2016 |
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Dr Jim Stewart
| Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division | 2016 |
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Dr Jim Stewart
| Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies | 2015 |
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Dr Jim Stewart
| Mitochondrial DNA: Radically free of free-radical driven mutations | 2015 |
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Dr Jim Stewart
| Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers | 2015 |
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Dr Jim Stewart
Professor Patrick Chinnery
| The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease | 2015 |
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Dr Jim Stewart
| The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication | 2015 |
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Dr Jim Stewart
| Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age | 2014 |
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Dr Jim Stewart
| Keeping mtDNA in shape between generations | 2014 |
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Dr Jim Stewart
| No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline | 2014 |
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Holly Baines
Dr Jim Stewart
Craig Stamp
Dr Anze Zupanic
Emeritus Professor Thomas Kirkwood
et al. | Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans | 2014 |
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Professor Patrick Chinnery
Dr Lyndsey Butterworth
Dr Jim Stewart
Professor Mary Herbert
Emeritus Professor Doug Turnbull
et al. | The Challenges of Mitochondrial Replacement | 2014 |
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Christoph Freyer
Dr Lynsey Cree
Dr Jim Stewart
Dr Vasileios Floros
Dr David Samuels
et al. | Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission | 2012 |
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Dr Jim Stewart
Dr Joanna Elson
| Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease | 2008 |
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