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Preface to the Special Issue “History, Biology and Pathobiology of Prions: A Field of Renewed Hopes”

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

© 2025 International Society for Neurochemistry.Research in the field of prion diseases has not only shed light on the mechanisms underlying transmissible spongiform encephalopathies (TSEs) but has also influenced the broader understanding of protein misfolding disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and other tauopathies and synucleinopathies. Although prion diseases are rare and invariably fatal, they have provided an invaluable conceptual framework for the study of age-associated neurodegenerative disorders. On the occasion of the “Prion 2023” meeting in Faro, Portugal, which brought together leading experts in prion biology and neurodegeneration to discuss emerging data and evolving concepts, we put together a special issue on the topic to discuss new structural insights, diagnostic technologies, and the increasing recognition of prion-like mechanisms in a wide range of proteinopathies. This Special Issue features six comprehensive review articles that highlight key advances and ongoing challenges in the study of prions and related disorders. (Figure presented.)

Publication metadata

Author(s): Outeiro TF, Vieira TCRG

Publication type: Editorial

Publication status: Published

Journal: Journal of Neurochemistry

Year: 2025

Volume: 169

Issue: 7

Print publication date: 01/07/2025

Online publication date: 13/07/2025

Acceptance date: 25/06/2025

ISSN (print): 0022-3042

ISSN (electronic): 1471-4159

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1111/jnc.70156

DOI: 10.1111/jnc.70156

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