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Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource

Lookup NU author(s): Mary Doona, Professor Chris LambORCiD

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Author(s): Roberts C, Peters J, Sazonvos A, Goodman N, Sharip M, Smith R, Bishara M, Bewshea C, Lin S, Chanchlani N, Hodges P, Badrulhisham F, Saifuddin A, Carlson S, Centritto A, Marley A, Saad M, Sethi-Aora K, White L, Abdelmeguid A, Pele L, Sebastian S, Selinger C, Irving P, Fachal L, Walker G, Palmer R, Kennedy N, Houghton J, Doona M, Lamb C, Hyde C, Parkes M, Goodhand J, Ahmad T

Publication type: Article

Publication status: Published

Journal: Alimentary Pharmacology and Therpapeutics

Year: 2025

Volume: 62

Issue: 6

Pages: 630-645

Print publication date: 01/09/2025

Online publication date: 23/06/2025

Acceptance date: 30/05/2025

Date deposited: 07/08/2025

ISSN (print): 0269-2813

ISSN (electronic): 1365-2036

Publisher: Wiley-Blackwell Publishing Ltd

URL: https://doi.org/10.1111/apt.70232

DOI: 10.1111/apt.70232

Data Access Statement: Individual participant de-identified raw data and a data dictionary de- fining each field in the set will be available on application from the IBD Bioresource. The data will be available after the application has been re- viewed by the NIHR data access committee. Proposals should be direct to the IBD Bioresource

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