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Lookup NU author(s): Karina Santiago Gonzalez, Dr Tim Boswell, Dr Tom SmuldersORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Introduction: Different functional domains can be identified along the longitudinal axis of the mammalian hippocampus. We have recently hypothesized that a similar functional gradient may exist along the longitudinal axis of the avian hippocampal formation (HF) as well. If the 2 gradients are homologous, we would expect the caudal HF to be more responsive to acute stress than the rostral HF. Methods: We restrained 8 adult Dekalb White hens in a bag for 30 min under red-light conditions and compared FOS-immunoreactive (FOS-ir) cell densities in different hippocampal subdivisions to control hens. Results: Although we could find no evidence of an activated stress response in the hypothalamic-pituitary-adrenal axis of the restrained birds, we did find a significant increase in FOS-ir cell densities in the rostral HF of the restrained birds compared to controls. Conclusion: We speculate that the HF response is not due to an acute stress response, but instead, it is related to the change in spatial context that was part of taking the birds and restraining them in a different room. We see no activation in the caudal HF. This would be consistent with our hypothesis that the longitudinal axis of the avian HF is homologous to the long axis of the mammalian hippocampus.
Author(s): Santiago Gonzalez K, Boswell T, Smulders TV
Publication type: Article
Publication status: Published
Journal: Brain, Behavior and Evolution
Year: 2025
Volume: 100
Issue: 2
Pages: 67-79
Print publication date: 01/06/2025
Online publication date: 01/11/2024
Acceptance date: 19/10/2024
Date deposited: 23/09/2025
ISSN (print): 0006-8977
ISSN (electronic): 1421-9743
Publisher: Karger
URL: https://doi.org/10.1159/000542207
DOI: 10.1159/000542207
ePrints DOI: 10.57711/d214-mr76
Data Access Statement: The data included in this manuscript will be made publicly available via the ZENODO platform, but have not been put there yet.
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