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Lookup NU author(s): Professor Viktor KorolchukORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025.Ageing is the primary risk factor for Parkinson’s disease, yet the intricate interplay between these processes remains ambiguous. This position paper, a collaborative output from the PD-AGE consortium, addresses the urgent need for standardising methods in in vitro modelling. A panel of international experts recommends human induced pluripotent stem cell (iPSC)-derived models, with chemically induced ageing methods, such as the SLO cocktail, as a robust system. Furthermore, the consortium highlights the value of direct and semi-direct reprogramming for retaining donor-specific ageing phenotypes. The paper also outlines a prioritised panel of measurable parameters, categorised into senescence, inflammaging, omics profiling, and mitochondrial dysfunction, providing a consistent framework to enhance research reproducibility, investigating the nexus of ageing and Parkinson’s. In addition, we provide links to SOPs (https://doi.org/10.5281/zenodo.15056603) [1] to measure the key measurable ageing parameters outlined in this review to facilitate consistency and reproducibility within the field.
Author(s): Bury AG, Olejnik A, Tocco C, Saurat N, Stephen E, Hockemeyer D, Schwamborn JC, Studer L, Mastroberardino PG, Bolognin S, Kunath T, Korolchuk VI, Drouin-Ouellet J, Mortiboys H
Publication type: Review
Publication status: Published
Journal: npj Parkinson's Disease
Year: 2025
Volume: 11
Issue: 1
Online publication date: 09/10/2025
Acceptance date: 27/08/2025
ISSN (electronic): 2373-8057
Publisher: Nature Research
URL: https://doi.org/10.1038/s41531-025-01137-2
DOI: 10.1038/s41531-025-01137-2
Data Access Statement: No datasets were generated or analysed during the current study.
