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Lookup NU author(s): Professor James ShawORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Recent three-dimensional (3D) analyses reported an abundance of small β cell-rich endocrine objects (EOs) in the human pancreas. Here, we used archival, immunolabeled 2D pancreas sections to assess morphological EO parameters in donors with or without type 1 diabetes (T1D), varying in age and disease duration. We confirm that abundant small, insulin-positive EOs are present in donors without diabetes and comprise most of the pancreatic endocrine area in early life. Small EOs are virtually absent in individuals with T1D, and this effect is most pronounced in children diagnosed with T1D in their earliest years. We conclude that extraislet β cells are affected in T1D development, and their early loss is a characteristic feature. This finding has important implications, which will inform future screening and treatment strategies for T1D.
Author(s): Murrall K, Luckett T, Lekka C, Flaxman CS, Wyatt R, Akhbari P, Kusmartseva I, Hunter SL, Leete P, Burn I, Osokina E, Shaw JAM, Morgan NG, Richardson SJ
Publication type: Article
Publication status: Published
Journal: Science Advances
Year: 2025
Volume: 11
Issue: 46
Online publication date: 12/11/2025
Acceptance date: 07/10/2025
Date deposited: 25/11/2025
ISSN (electronic): 2375-2548
Publisher: American Association for the Advancement of Science
URL: https://doi.org/10.1126/sciadv.adz2251
DOI: 10.1126/sciadv.adz2251
Data Access Statement: The EADB, nPOD, HDBR, QUOD, DiViD, and EUnPOD resources can be provided by the appropriate research tissue banks, pending scientific review and completion of a material transfer agreement. Select tissue samples and images from donors evaluated as part of this study can be requested from nPOD for use in projects approved by the nPOD Tissue Prioritisation Committee, as outlined on the nPOD website (www.npod.org). Requests for the EADB biobank should be directed to s.richardson@exeter.ac.uk. Requests for access to the HDBR should be directed to www.hdbr.org/about. Requests for access to the QUOD biobank should be directed to jim.shaw@newcastle.ac.uk. Requests for access to the DiViD biobank should be directed to knut.dahl-jorgensen@medisin.uio.no. Requests for access to the EUnPOD biobank should be directed to francesco.dotta@unisi.it. This study did not generate new unique reagents. The rest of the data access statement is available in the paper.
PubMed id: 41223263
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