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Lookup NU author(s): Professor Bob Anderson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 Heart Rhythm Society.Pacing of the atrial chambers has recently gained increased attention. However, major barriers relate to the understanding of the underlying anatomy relative to fluoroscopic positioning of pacing leads and the reliance on using the morphology of the electrocardiographic P-wave in guiding the intended capture of the preferential pathways for interatrial conduction. There remains a gap in knowledge in the understanding of both the location of the sinus and atrioventricular nodes and the arrangement of the intervening myocardial preferential conduction pathways, coupled with an appreciation of how to apply such understanding toward guiding and improving the success rate of pacing procedures. In this review, we delineate the 3-dimensional anatomy of the atriums and show how this relates to the pathways for atrial conduction. Although we recognize that, as yet, the locations of the sinus and atrioventricular nodes cannot be shown directly when using clinical imaging, we describe and illustrate how interrogation using 3-dimensional cardiac computed tomography is now able to accurately predict their location, along with the preferential pathways of electrical atrial activation. We submit that such understanding may provide practical guidance for those undertaking pacing procedures, permitting the personalization of cardiac care related to atrial conduction.
Author(s): Tretter JT, Ponnusamy SS, Vijayaraman P, Cook AC, Sanchez-Quintana D, Anderson RH, Ben-Haim S
Publication type: Review
Publication status: Published
Journal: Heart Rhythm
Year: 2026
Volume: 23
Issue: 1
Pages: 131-142
Print publication date: 01/01/2026
Online publication date: 02/01/2026
Acceptance date: 02/04/2025
ISSN (print): 1547-5271
ISSN (electronic): 1556-3871
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.hrthm.2025.09.032
DOI: 10.1016/j.hrthm.2025.09.032
PubMed id: 41033591
