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Methotrexate with thymidine, inosine, and allopurinol rescue - a phase-I clinical-study

Lookup NU author(s): Geoffrey Taylor, Professor Alan Calvert


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A phase I clinical study of a combination of thymidine (TdR), inosine (IR), and allopurinol used as rescue from 24-hour infusions of methotrexate (MTX) was undertaken following animal studies that had shown a better preservation of antitumor activity with this system than with folinic acid. TdR and IR were given in the dose ratio 5:1 by weight throughout. Rescue from MTX, 400 mg/m2, could be achieved with a TdR dose in the combination of 1 g/m2/24 hours. This same rescue was also effective when the MTX dose was increased to 800 mg/m2, but only partly effective at an MTX dose of 1.5 g/m2. It was not necessary to raise the levels of circulating nucleosides significantly above normal to achieve rescue. MTX-related skin lesions occurred more frequently than might be expected with the MTX dose used.

Publication metadata

Author(s): Dady PJ, Taylor GA, Muindi JFR, Calvert AH, Smith IE, Smyth JF, Harrap KR

Publication type: Article

Publication status: Published

Journal: Cancer Treatment Reports

Year: 1981

Volume: 65

Issue: Supplement 1

Pages: 37-43

ISSN (print): 0361-5960

PubMed id: 7326664