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Lookup NU author(s): Dr Ian Cowell
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The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation.
Author(s): Jones DO, Cowell IG, Singh PB
Publication type: Article
Publication status: Published
ISSN (print): 0265-9247
ISSN (electronic): 1521-1878
Publisher: John Wiley & Sons Ltd.
PubMed id: 10655032
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