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Mammalian chromodomain proteins: their role in genome organisation and expression

Lookup NU author(s): Dr Ian Cowell

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Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation.


Publication metadata

Author(s): Jones DO, Cowell IG, Singh PB

Publication type: Article

Publication status: Published

Journal: BioEssays

Year: 2000

Volume: 22

Issue: 2

Pages: 124-137

ISSN (print): 0265-9247

ISSN (electronic): 1521-1878

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

DOI: 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

PubMed id: 10655032


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