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The gene and pseudogenes of Cbx3/mHP1 gamma

Lookup NU author(s): Dr Ian Cowell

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Abstract

The HP1 class of chromobox (Cbx) genes encode an evolutionarily conserved family of proteins involved in the packaging of chromosomal domains into a repressive heterochromatic state. The murine Cbx5, Cbx1 and Cbx3 genes encode the three mouse HP1 proteins, mHP1 alpha, -beta and -gamma respectively. Here, we report the cloning of the mouse Cbx3/HP1 gamma gene and the chromosomal localisation of Cbx3 and three Cbx3-related pseudogenes. The Cbx3 structural gene is located on mouse Chromosome 6, close to the Hoxa cluster. Two Cbx3 processed pseudogenes are separated by just 300 bp and are arranged in a head-to-tail configuration on Chromosome 13 while a third pseudogene is found on mouse Chromosome 4. The genomic intron-exon arrangement of Cbx3 is different from the conserved organisation of three other mammalian HP1 genes, Cbx1 (mHP1 beta), CBX3 (hHP1 gamma), and Cbx5 (mHP1 alpha) in that Cbx3 lacks an intron that is present in the others


Publication metadata

Author(s): Jones DO, Mattei MG, Horsley D, Cowell IG, Singh PB

Publication type: Article

Publication status: Published

Journal: DNA sequence

Year: 2001

Volume: 12

Issue: 3

Pages: 147-160

ISSN (print): 1042-5179

ISSN (electronic): 1029-2365

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/10425170109080769

DOI: 10.3109/10425170109080769

PubMed id: 11762190


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