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Acute lymphoblastic leukemia following Hodgkins Disease is associated with a poor prognosis

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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Summary. Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.

Publication metadata

Author(s): Narayanan MN, Morgenstern GR, Chang JC, Harrison CJ, Ranson, Scarffe JH

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 1994

Volume: 86

Issue: 4

Pages: 867-869

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1365-2141.1994.tb04844.x


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