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Transcriptional repression by a novel member of the bZIP family of transcription factors

Lookup NU author(s): Dr Ian Cowell


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We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors

Publication metadata

Author(s): Cowell IG, Skinner A, Hurst HC

Publication type: Article

Publication status: Published

Journal: Molecular & Cellular Biology

Year: 1992

Volume: 12

Issue: 7

Pages: 3070-3077

Print publication date: 01/07/1992

ISSN (print): 0270-7306

ISSN (electronic): 1098-5549

Publisher: American Society for Microbiology


PubMed id: 1620116