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Lookup NU author(s): Dr Ian CowellORCiD
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We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors
Author(s): Cowell IG, Skinner A, Hurst HC
Publication type: Article
Publication status: Published
Journal: Molecular & Cellular Biology
Year: 1992
Volume: 12
Issue: 7
Pages: 3070-3077
Print publication date: 01/07/1992
ISSN (print): 0270-7306
ISSN (electronic): 1098-5549
Publisher: American Society for Microbiology
URL: http://mcb.asm.org/cgi/reprint/12/7/3070
PubMed id: 1620116
