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The structure of the human glutathione-Pi gene

Lookup NU author(s): Dr Ian Cowell

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Abstract

The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer


Publication metadata

Author(s): Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB

Publication type: Article

Publication status: Published

Journal: Biochemical Journal

Year: 1988

Volume: 255

Issue: 1

Pages: 79-83

Print publication date: 01/10/1988

ISSN (print): 0264-6021

ISSN (electronic): 1470-8728

Publisher: Portland Press Ltd.

URL: http://www.biochemj.org/bj/255/bj2550079.htm

PubMed id: 3196325


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