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Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis

Lookup NU author(s): Professor John LoughlinORCiD


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From a prospective, cross-sectional survey of 402 patients who had a total hip (THR) or a total knee (TKR) replacement for idiopathic osteoarthritis (OA) at a major centre, we determined the prevalence of these replacements for idiopathic OA in their 1171 siblings and 376 spouses. Using spouses as controls, the relative risk of THR in siblings was 1.86 (95% CI 0.93 to 3.69). The relative risk for TKR in siblings v spouses was 4.8 (95 % CI 0.64 to 36.4) whereas the risk for the combined outcome measure of THR or TKR was 2.32 (95% CI 1.22 to 4.43) when siblings and spouses over 64 years of age were compared. Using a threshold liability model (Falconer), the heritability of end-stage OA of the hip was estimated at 27%. The increased risks of joint replacement for severe, idiopathic OA which we found in siblings suggest that genetic influences are important in end-stage OA of the hip and knee.

Publication metadata

Author(s): Chitnavis J, Sinsheimer JS, Clipsham K, Loughlin J, Sykes B, Burge PD, Carr AJ

Publication type: Article

Publication status: Published

Journal: Journal of Bone and Joint Surgery

Year: 1997

Volume: 79

Issue: 4

Pages: 660-4

Print publication date: 01/07/1997

ISSN (print): 0301-620X

Publisher: British Editorial Society of Bone and Joint Surgery


DOI: 10.1302/0301-620x.79b4.7437

Notes: Journal Article Research Support, Non-U.S. Gov't England


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