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Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage

Lookup NU author(s): Professor John LoughlinORCiD

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Abstract

We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P

Publication metadata

Author(s): Loughlin J; Chapman K; Mustafa Z; Irven C; Carr AJ; Clipsham K; Smith A; Chitnavis J; Sinsheimer JS; Bloomfield VA; McCartney M; Cox O; Cardon LR; Sykes B

Publication type: Article

Publication status: Published

Journal: American Journal of Human Genetics

Year: 1999

Volume: 65

Issue: 1

Pages: 167-174

Print publication date: 01/07/1999

ISSN (print): 0002-9297

ISSN (electronic): 1537-6605

Publisher: Cell Press

URL: http://dx.doi.org/10.1086/302465

DOI: 10.1086/302465

Notes: Journal Article Research Support, Non-U.S. Gov't United states

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