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Dinucleotide-sensing proteins: linking signaling networks and regulating transcription

Lookup NU author(s): Dr Heather Lamb, Professor Alastair Hawkins


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Differential binding of dinucleotides to key regulatory proteins can modulate their interactions with other proteins and, in some cases, can signal fluctuations in the cellular redox state, to produce changes in transcription and physiological state. The dinucleotide-binding proteins human HSCARG and yeast transcription repressor Gal80p are examples that offer exciting glimpses into the potential for dinucleotide-sensing proteins to couple fluctuations in dinucleotide ratios to changes in transcription and to act as networking agents linking different classes of signaling molecules.

Publication metadata

Author(s): Lamb HK, Stammers DK, Hawkins AR

Publication type: Article

Publication status: Published

Journal: Science Signaling

Year: 2008

Volume: 1

Issue: 33

Pages: pe38

ISSN (print): 1945-0877

ISSN (electronic): 1937-9145

Publisher: American Association for the Advancement of Science


DOI: 10.1126/scisignal.133pe38

PubMed id: 18714085

Notes: Journal Article United States


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