Publications by Professor Alastair Hawkins - ePrints

Browsing publications by Professor Alastair Hawkins.

Newcastle Authors	Title	Year
Dr David Wilkinson Angie Habgood Dr Heather Lamb Paul Thompson Professor Alastair Hawkins et al.	Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms	2017
Paul Thompson Professor Alastair Hawkins	Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy	2016
Dr Artur Rogowski Jon Briggs Dr Elisabeth Lowe Dr Arnaud Basle Carl Morland et al.	Glycan complexity dictates microbial resource allocation in the large intestine	2015
Paul Thompson Professor Alastair Hawkins	Irreversible covalent modification of type I dehydroquinase with a stable Schiff base	2015
Paul Thompson Professor Alastair Hawkins	Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors	2014
Paul Thompson Professor Alastair Hawkins	Insights into substrate binding and catalysis in bacterial type I dehydroquinase	2014
Dr Heather Lamb Professor Alastair Hawkins	Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases	2014
Professor Alastair Hawkins	Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover	2013
Dr Heather Lamb Paul Thompson Professor Alastair Hawkins	Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex	2013
Shaun Martin Dr Heather Lamb Paul Thompson Professor Penny Lovat Professor Alastair Hawkins et al.	Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78	2013
Dr Heather Lamb Professor Alastair Hawkins	Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids	2013
Dr Heather Lamb Professor Alastair Hawkins	Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1	2012
Professor Alastair Hawkins	Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency	2012
Dr Heather Lamb Professor Alastair Hawkins	A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors	2011
Dr Heather Lamb Professor Alastair Hawkins	Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351	2011
Professor Alastair Hawkins	Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form	2011
Dr Heather Lamb Professor Alastair Hawkins	Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase	2011
Dr Heather Lamb Professor Alastair Hawkins	Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase	2010
Professor Alastair Hawkins	Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues	2010
Elaine Zhao Samantha Hume Dr Christopher Johnson Paul Thompson Dr Jun-yong Huang et al.	The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases	2010
Dr Heather Lamb Professor Alastair Hawkins	Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids	2010
Dr Heather Lamb Professor Alastair Hawkins	2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase	2009
Dr Heather Lamb Professor Alastair Hawkins	Competitive inhibitors of Helicobacter pylori type II dehydroquinase: Synthesis, biological evaluation, and NMR studies	2008
Professor Alastair Hawkins	Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein	2008
Dr Heather Lamb Professor Alastair Hawkins	Dinucleotide-sensing proteins: linking signaling networks and regulating transcription	2008
Dr Heather Lamb Professor Alastair Hawkins	MbeA and MbeC, proteins key to ColE1 plasmid mobilisation, interact in vitro with a 1 : 1 stoichiometry	2008
Dr Heather Lamb Professor Alastair Hawkins	Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA	2008
Dr Heather Lamb Professor Alastair Hawkins	Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases	2007
Dr Heather Lamb Paul Thompson Dr Nick Watkins Professor Alastair Hawkins	Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium	2007
Dr Heather Lamb Professor Alastair Hawkins	Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase	2007
Dr Heather Lamb Professor Alastair Hawkins	Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium	2007
Dr Heather Lamb Professor Alastair Hawkins	Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy	2006
Dr Christopher Johnson Dr Heather Lamb Professor Alastair Hawkins	Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog	2006
Professor Alastair Hawkins	Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5′-monophosphate	2006
Professor Alastair Hawkins	Structure of Staphylococcus aureus guanylate monophosphate kinase	2006
Professor Alastair Hawkins	Structure of Staphylococcus aureus guanylate monophosphate kinase	2006
Professor Alastair Hawkins	Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding	2006
Professor Alastair Hawkins	Structures of R- and T-state Escherichia coli aspartokinase III: Mechanisms of the allosteric transition and inhibition by lysine	2006
Dr Heather Lamb Christopher Mee Professor Alastair Hawkins	The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP	2006
Dr Heather Lamb Professor Alastair Hawkins	GTP cyclohydrolase II structure and mechanism	2005
Professor Alastair Hawkins	Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase	2005
Dr Alison Park Dr Heather Lamb Professor Alastair Hawkins	Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein	2004
Professor Alastair Hawkins	Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases	2004
Professor Alastair Hawkins	Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments	2004
Professor Alastair Hawkins	Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase	2004
Professor Alastair Hawkins	High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate β-semialdehyde dehydrogenase	2004
Dr Heather Lamb Dr Alison Park Dr Christopher Johnson Dr Simon Cocklin Paul Thompson et al.	Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis	2004
Professor Alastair Hawkins	Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 Å resolution from crystals grown following enzyme turnover	2004
Dr Heather Lamb Professor Alastair Hawkins	Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase	2003
Dr Heather Lamb Dr Anna Dodds Dr Christopher Johnson Professor Alastair Hawkins	The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides	2003
Professor Alastair Hawkins	Twists and turns: A tale of two shikimate-pathway enzymes	2003
Professor Alastair Hawkins Dr Heather Lamb	A thermodynamic study of the reactions: {2-dehydro-3-deoxy-D-arabino-heptanoate 7-phosphate(aq) = 3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq) = 3-dehydroshikimate(aq) + H2O(1)}	2002
Professor Alastair Hawkins	Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity	2002
Professor Alastair Hawkins	Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus	2002
Dr Carys Watts Dr Heather Lamb Professor Alastair Hawkins	Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins	2002
Dr Alison Spiers Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins et al.	PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide	2002
Dr Simon Cocklin Dr Anna Dodds Dr Heather Lamb Professor Alastair Hawkins	Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression	2001
Dr Heather Lamb Faye Haldane Professor Alastair Hawkins	Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase	2001
Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins	The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases	2001
Dianne Smith Dr Heather Lamb Professor Alastair Hawkins	Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein	2000
Professor Alastair Hawkins	Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids	2000
Professor Alastair Hawkins	Selective inhibition of type II dehydroquinases	1999
Professor Alastair Hawkins	Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids	1999
Dr Richard Virden Professor Alastair Hawkins	The folding and assembly of the dodecameric type II dehydroquinases	1999
Dr Richard Virden Professor Alastair Hawkins	The folding and assembly of the dodecameric type II dehydroquinases	1999
Professor Alastair Hawkins	The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction	1999