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Browsing publications by Professor Alastair Hawkins.

Newcastle AuthorsTitleYearFull text
Dr David Wilkinson
Angie Habgood
Dr Heather Lamb
Paul Thompson
Professor Alastair Hawkins
et al.
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms2017
Paul Thompson
Professor Alastair Hawkins
Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy2016
Dr Artur Rogowski
Jon Briggs
Dr Elisabeth Lowe
Dr Arnaud Basle
Carl Morland
et al.
Glycan complexity dictates microbial resource allocation in the large intestine2015
Paul Thompson
Professor Alastair Hawkins
Irreversible covalent modification of type I dehydroquinase with a stable Schiff base2015
Paul Thompson
Professor Alastair Hawkins
Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors2014
Paul Thompson
Professor Alastair Hawkins
Insights into substrate binding and catalysis in bacterial type I dehydroquinase2014
Dr Heather Lamb
Professor Alastair Hawkins
Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases2014
Professor Alastair Hawkins
Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover2013
Dr Heather Lamb
Paul Thompson
Professor Alastair Hawkins
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex2013
Shaun Martin
Dr Heather Lamb
Paul Thompson
Professor Penny Lovat
Professor Alastair Hawkins
et al.
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP782013
Dr Heather Lamb
Professor Alastair Hawkins
Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids2013
Dr Heather Lamb
Professor Alastair Hawkins
Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE12012
Professor Alastair Hawkins
Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency2012
Dr Heather Lamb
Professor Alastair Hawkins
A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors2011
Dr Heather Lamb
Professor Alastair Hawkins
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM43512011
Professor Alastair Hawkins
Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form2011
Dr Heather Lamb
Professor Alastair Hawkins
Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase2011
Dr Heather Lamb
Professor Alastair Hawkins
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase2010
Professor Alastair Hawkins
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues2010
Elaine Zhao
Samantha Hume
Dr Christopher Johnson
Paul Thompson
Dr Jun-yong Huang
et al.
The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases2010
Dr Heather Lamb
Professor Alastair Hawkins
Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids2010
Dr Heather Lamb
Professor Alastair Hawkins
2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase2009
Dr Heather Lamb
Professor Alastair Hawkins
Competitive inhibitors of Helicobacter pylori type II dehydroquinase: Synthesis, biological evaluation, and NMR studies2008
Professor Alastair Hawkins
Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein2008
Dr Heather Lamb
Professor Alastair Hawkins
Dinucleotide-sensing proteins: linking signaling networks and regulating transcription2008
Dr Heather Lamb
Professor Alastair Hawkins
MbeA and MbeC, proteins key to ColE1 plasmid mobilisation, interact in vitro with a 1 : 1 stoichiometry2008
Dr Heather Lamb
Professor Alastair Hawkins
Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA2008
Dr Heather Lamb
Professor Alastair Hawkins
Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases2007
Dr Heather Lamb
Paul Thompson
Dr Nick Watkins
Professor Alastair Hawkins
Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium2007
Dr Heather Lamb
Professor Alastair Hawkins
Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase2007
Dr Heather Lamb
Professor Alastair Hawkins
Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium2007
Dr Heather Lamb
Professor Alastair Hawkins
Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy2006
Dr Christopher Johnson
Dr Heather Lamb
Professor Alastair Hawkins
Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog2006
Professor Alastair Hawkins
Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5′-monophosphate2006
Professor Alastair Hawkins
Structure of Staphylococcus aureus guanylate monophosphate kinase2006
Professor Alastair Hawkins
Structure of Staphylococcus aureus guanylate monophosphate kinase2006
Professor Alastair Hawkins
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding2006
Professor Alastair Hawkins
Structures of R- and T-state Escherichia coli aspartokinase III: Mechanisms of the allosteric transition and inhibition by lysine2006
Dr Heather Lamb
Christopher Mee
Professor Alastair Hawkins
The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP2006
Dr Heather Lamb
Professor Alastair Hawkins
GTP cyclohydrolase II structure and mechanism2005
Professor Alastair Hawkins
Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase2005
Dr Alison Park
Dr Heather Lamb
Professor Alastair Hawkins
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein2004
Professor Alastair Hawkins
Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases2004
Professor Alastair Hawkins
Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments2004
Professor Alastair Hawkins
Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase2004
Professor Alastair Hawkins
High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate β-semialdehyde dehydrogenase2004
Dr Heather Lamb
Dr Alison Park
Dr Christopher Johnson
Dr Simon Cocklin
Paul Thompson
et al.
Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis2004
Professor Alastair Hawkins
Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 Å resolution from crystals grown following enzyme turnover2004
Dr Heather Lamb
Professor Alastair Hawkins
Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase2003
Dr Heather Lamb
Dr Anna Dodds
Dr Christopher Johnson
Professor Alastair Hawkins
The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides2003
Professor Alastair Hawkins
Twists and turns: A tale of two shikimate-pathway enzymes2003
Professor Alastair Hawkins
Dr Heather Lamb
A thermodynamic study of the reactions: {2-dehydro-3-deoxy-D-arabino-heptanoate 7-phosphate(aq) = 3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq) = 3-dehydroshikimate(aq) + H2O(1)}2002
Professor Alastair Hawkins
Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity2002
Professor Alastair Hawkins
Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus2002
Dr Carys Watts
Dr Heather Lamb
Professor Alastair Hawkins
Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins2002
Dr Alison Spiers
Dr Heather Lamb
Dr Simon Cocklin
Dr Anna Dodds
Professor Alastair Hawkins
et al.
PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide2002
Dr Simon Cocklin
Dr Anna Dodds
Dr Heather Lamb
Professor Alastair Hawkins
Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression2001
Dr Heather Lamb
Faye Haldane
Professor Alastair Hawkins
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase2001
Dr Heather Lamb
Dr Simon Cocklin
Dr Anna Dodds
Professor Alastair Hawkins
The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases2001
Dianne Smith
Dr Heather Lamb
Professor Alastair Hawkins
Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein2000
Professor Alastair Hawkins
Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids2000
Professor Alastair Hawkins
Selective inhibition of type II dehydroquinases1999
Professor Alastair Hawkins
Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids1999
Dr Richard Virden
Professor Alastair Hawkins
The folding and assembly of the dodecameric type II dehydroquinases1999
Dr Richard Virden
Professor Alastair Hawkins
The folding and assembly of the dodecameric type II dehydroquinases1999
Professor Alastair Hawkins
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction1999