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In vivo loss of telomeric repeats with age in humans

Lookup NU author(s): Dr Janet Lindsey

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Abstract

Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.

Publication metadata

Author(s): Lindsey JC, McGill NI, Lindsey LA, Green DK, Cooke HJ

Publication type: Article

Publication status: Published

Journal: Mutation Research - DNAging

Year: 1991

Volume: 256

Issue: 1

Pages: 45-48

Print publication date: 01/01/1991

ISSN (print): 0921-8734

ISSN (electronic): 1568-7864

Publisher: Elsevier B.V.

URL: http://dx.doi.org/10.1016/0921-8734(91)90032-7

DOI: 10.1016/0921-8734(91)90032-7

PubMed id: PMID: 1944

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