Publications by Dr Janet Lindsey - ePrints

Browsing publications by Dr Janet Lindsey.

Newcastle Authors	Title	Year
Dr Ed Schwalbe Dr Janet Lindsey Dr Marina Danilenko Dr Rebecca Hill Dr Stephen Crosier et al.	Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study	2025
Magretta Adiamah Beth Poole Dr Janet Lindsey Dr Rebecca Hill Dr Helen Blair et al.	MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma	2025
Dr Stacey Richardson Dr Rebecca Hill Dr Christopher Kui Dr Janet Lindsey Dr Yura Grabovska et al.	Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse	2022
Dr Daniel Williamson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey Dr Stephen Crosier et al.	Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development	2022
Dr Stephen Crosier Dr Debbie Hicks Dr Ed Schwalbe Dr Daniel Williamson Amanda Smith et al.	Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics	2021
Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al.	The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes	2021
Dr Yura Grabovska Dr Stephen Crosier Dr Martina Finetti Dr Ed Schwalbe Dr Rebecca Hill et al.	Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity	2020
Dr Rebecca Hill Dr Stacey Richardson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey et al.	Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study	2020
Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dr Rebecca Hill Dr Debbie Hicks et al.	Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes	2019
Professor Steven Clifford Dr Debbie Hicks Dr Janet Lindsey Dr Rebecca Hill	Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours	2017
Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al.	Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures	2017
Dr Ed Schwalbe Dr Janet Lindsey Dr Sirintra Nakjang Dr Stephen Crosier Amanda Smith et al.	Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study	2017
Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford	Divergent clonal selection dominates medulloblastoma at recurrence	2016
Dr Janet Lindsey Dr Rebecca Hill Dr Ed Schwalbe Dr Christopher Howell Dr Reza Rafiee et al.	Molecular and Prognostic Heterogeneity within MYC and MYCN Amplified Medulloblastomas	2016
Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al.	Subgroup-Directed Stratification of Risk in Infant Medulloblastoma	2016
Dr Daniel Williamson Dr Janet Lindsey Dr Debbie Hicks Dr Stephen Crosier Amanda Smith et al.	The Transcriptional Landscape of Medulloblastoma: Group 3 and Group 4 Tumours Comprise a Single Clinically Significant Expression Continuum	2016
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al.	Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease	2015
Dr Janet Lindsey Dr Ed Schwalbe Matthew Selby Dr James Hayden Dr Daniel Williamson et al.	Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance	2015
Dr Janet Lindsey Dr Ed Schwalbe Sandeep Potluri Professor Simon Bailey Dr Daniel Williamson et al.	TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours	2014
Dr Janet Lindsey Dr Ed Schwalbe Dr James Hayden Professor David Ellison Dr Daniel Williamson et al.	Cross-Species Epigenetics Identifies a Critial Role for VAV1 in the Maintenance of Sonic Hedgehog Subgroup Medulloblastomas	2014
Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford	Cytogenetic Prognostication Within Medulloblastoma Subgroups	2014
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Daniel Williamson Dr Sarra Ryan et al.	MYC and TP53 defects emerge and interact at medulloblastoma relapse, define rapidly progressive disease and can be targeted therapeutically	2014
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al.	MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically	2014
Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dolores Hamilton Sarra Ryan et al.	DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies	2013
Dr Ed Schwalbe Dr James Hayden Dr Janet Lindsey Dr Rebecca Hill Sarah Nicholson et al.	Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types	2013
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Professor Simon Bailey Professor Steven Clifford et al.	Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma	2013
Dr Ed Schwalbe Dr Janet Lindsey Dr Daniel Williamson Kieran O'Toole Dr Meryl Lusher et al.	Epigenetic sub-classification and risk-stratification of medulloblastoma using DNA methylomics	2012
Dr Janet Lindsey Professor Simon Bailey Professor Steven Clifford	Subgroup-specific structural variation across 1,000 medulloblastoma genomes	2012
Dr Ed Schwalbe Dr Janet Lindsey Debbie Straughton Mike Cole Dr Hisham Megahed et al.	Rapid Diagnosis of Medulloblastoma Molecular Subgroups	2011
Dr Meryl Lusher Dr Janet Lindsey Professor Steven Clifford	RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines	2011
Dr Janet Lindsey Dr Rebecca Hill Dr Hisham Megahed Dr Meryl Lusher Dr Ed Schwalbe et al.	TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas	2011
Dr Ed Schwalbe Dr Janet Lindsey Dr Meryl Lusher Kieran O'Toole Sarah Nicholson et al.	DNA methylomics identifies clinically significant epigenetic subgroups of medulloblastoma	2010
Dr James Hayden Dr Matthew Allen Dr Sarra Ryan Sarah Nicholson Dr Ed Schwalbe et al.	Molecular Mechanisms in Supratentorial CNS-PNET development	2010
Dr Janet Lindsey Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson	Subtypes of medulloblastoma have distinct developmental origins	2010
Dr Janet Lindsey Professor Steven Clifford	Methylation-Controlled J Protein	2009
Jennifer Anderton Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Simon Bailey et al.	Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2	2008
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al.	Wnt-pathway medulloblastomas	2008
Professor David Ellison Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford	Beta-catenin status predicts favorable prognosis in childhood medulloblastoma	2007
Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Dr Richard Gilbertson Professor David Ellison et al.	Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma	2007
Olabisi Onilude Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison et al.	APC and CTNNB1 mutations are rare in sporadic ependymomas	2006
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Robert Brown Dr Richard Gilbertson et al.	Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours	2006
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Dr Richard Gilbertson Professor Simon Bailey et al.	Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours	2006
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al.	Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis	2006
Professor David Ellison Olabisi Onilude Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson et al.	β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee	2005
Dr Janet Lindsey Jennifer Anderton Dr Meryl Lusher Professor Steven Clifford	Epigenetic events in medulloblastoma development	2005
David Hamilton Dr Meryl Lusher Dr Janet Lindsey Professor David Ellison Professor Steven Clifford et al.	Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma	2005
Professor Steven Clifford Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Andrew Pearson et al.	Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling	2004
Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Professor Simon Bailey Dr Richard Gilbertson et al.	Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling	2004
Dr Adrian Frank Roberto Hernan Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford et al.	The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma	2004
Dr Janet Lindsey Dr Meryl Lusher Professor Mark Birch-Machin	Current pitfalls in the measurement of the 4977 bp mitochondrial DNA common deletion in human skin	2003
Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al.	Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling	2003
Dr Debbie Scott Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison et al.	Identification of tumour suppressor loci on chromosome 10q in medulloblastoma	2003
Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al.	Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development	2002
Dr Janet Lindsey Dr Meryl Lusher Emerita Professor Katherine Bushby Professor Pamela Shaw	Genotype-phenotype correlation in hereditary spastic paraparesis	2001
Dr Meryl Lusher Dr Janet Lindsey Emeritus Professor Doug Turnbull Emerita Professor Katherine Bushby Professor Pamela Shaw et al.	Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England.	2001
Dr Kathleen White Dr Meryl Lusher Dr Janet Lindsey Professor Pamela Shaw Emerita Professor Katherine Bushby et al.	Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation	2000
Dr Janet Lindsey Dr Meryl Lusher Dr Kathleen White Dr Rumaisa Bashir Professor Pamela Shaw et al.	Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis	2000
Dr Janet Lindsey	Replication strand preference for deletions associated with DNA palindromes	1998
Simon Carter Dr Janet Lindsey Dr Rumaisa Bashir	A new locus for autosomal dominant retinitis pigmentosa on chromosome 7p	1993
Dr Janet Lindsey Dr Surinder Papiha	Exclusion of chromosome 6 and 8 locations in nonrhodopsin autosomal dominant retinitis pigmentosa families: further locus heterogeneity in adRP	1992
Dr Janet Lindsey	Recombination between rhodopsin and locus D3S47 (C17) in rhodopsin retinitis pigmentosa families	1992
Dr Janet Lindsey	In vivo loss of telomeric repeats with age in humans	1991
Dr Janet Lindsey	The structure of a subterminal repeated sequence present on many human chromosomes	1990
Dr Janet Lindsey	Slow replication of palindrome-containing DNA	1989
Dr Janet Lindsey	Genome interactions which influence DNA palindrome mediated instability and inviability in Escherichia coli	1987
Dr Janet Lindsey	In vivo loss of supercoiled DNA carrying a palindromic sequence	1986