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Lookup NU author(s): Dr Janet Lindsey,
Dr Surinder Papiha
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Genetic studies have revealed that 25 to 30% of autosomal dominant retinitis pigmentosa (adRP) families have mutations in the rhodopsin gene, while the remainder do not. More recently linkage data and mutation detection have demonstrated two further loci implicated in adRP, at an as yet unidentified gene on chromosome 8p and at the human gene homologue of the mouse Rds (Retinal Degeneration Slow) gene on chromosome 6p. We have previously reported exclusion of adRP from the rhodopsin locus on 3q in two large adRP families. We now report exclusion data for both families, on chromosomes 6 and 8, demonstrating that the adRP phenotype results from mutations in at least four locations.
Author(s): Bashir R, Inglehearn CF, Keen TJ, Lindsey JC, Atif U, Carter SA, Stephenson AM, Jackson A, Jay M, Bird AC, Papiha SS, Bhattacharya SS
Publication type: Article
Publication status: Published
Print publication date: 01/09/1992
ISSN (print): 0888-7543
ISSN (electronic): 1089-8646
Publisher: Academic Press
PubMed id: PMID: 1427
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