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Lookup NU author(s): Dr Stuart Kendrick, Professor David Jones
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The pathogenesis of the sepsis syndrome is critically dependent upon activation of the innate immune response. Innate immunity plays a direct role in the development of sepsis and is also crucial for the activation and modulation of later antigen-specific adaptive immune responses. Nearly all the clinical manifestations of sepsis and the systemic inflammatory response syndrome (SIRS) can be attributed to components of the innate immune response. However, this review will focus on the new and expanding field of innate immune activation by pathogen-responsive receptors, most importantly the toll-like receptors (TLRs).
Author(s): Kendrick SFW, Jones DEJ
Editor(s): Baudouin, SV
Publication type: Book Chapter
Publication status: Published
Book Title: Sepsis
Year: 2007
Pages: 5-10
Edition: 1st
Series Title: Competency-based Critical Care
Publisher: Springer-Verlag
Place Published: London
Library holdings: Search Newcastle University Library for this item
ISBN: 9781846289385
