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Mechanisms of Innate Immunity in Sepsis

Lookup NU author(s): Dr Stuart Kendrick, Professor David Jones


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The pathogenesis of the sepsis syndrome is critically dependent upon activation of the innate immune response. Innate immunity plays a direct role in the development of sepsis and is also crucial for the activation and modulation of later antigen-specific adaptive immune responses. Nearly all the clinical manifestations of sepsis and the systemic inflammatory response syndrome (SIRS) can be attributed to components of the innate immune response. However, this review will focus on the new and expanding field of innate immune activation by pathogen-responsive receptors, most importantly the toll-like receptors (TLRs).

Publication metadata

Author(s): Kendrick SFW, Jones DEJ

Editor(s): Baudouin, SV

Publication type: Book Chapter

Publication status: Published

Book Title: Sepsis

Year: 2007

Pages: 5-10

Edition: 1st

Series Title: Competency-based Critical Care

Publisher: Springer-Verlag

Place Published: London

Library holdings: Search Newcastle University Library for this item

ISBN: 9781846289385