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Cyclophosphamide pharmacokinetics in children

Lookup NU author(s): Professor Alan Boddy, Mike Cole, Professor Andrew Pearson

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Abstract

1. Cyclophosphamide pharmacokinetics were measured in 38 children with cancer. 2. A high degree of inter-patient variation was seen in all pharmacokinetic parameters. Cyclophosphamide half-life varied between 1.1. and 16.8 h, clearance varied between 1.2 and 10.6 l h-1 m-2 and volume of distribution varied between 0.26 and 1.48 l kg-1. 3. The half-life of cyclophosphamide was prolonged at high dose levels (P = 0.008). 4. Children who had received prior treatment with dexamethasone showed a mean increase in clearance of 2.5 1 h-1 m-2 (P = 0.001) presumably as a result of CYP450 enzyme induction. 5. Treatment with alopurinol or chlorpromazine was associated with a significant increase in cyclophosphamide half-life (P < 0.001 in both cases). 6. Dose and concurrent treatment may influence cyclophosphamide metabolism in vivo and thus potentially alter the drugs therapeutic effect.


Publication metadata

Author(s): Yule, S., Boddy, A. V., Cole, M., Price, L., Wyllie, R., Tasso, M., Pearson, A. D. J., Idle, J.

Publication type: Article

Publication status: Published

Journal: British Journal of Clinical Pharmacology

Year: 1996

Volume: 41

Issue: 1

Pages: 13-19

Print publication date: 01/01/1996

ISSN (print): 0306-5251

ISSN (electronic): 1365-2125

URL: http://dx.doi.org/10.1111/j.1365-2125.1996.tb00153.x

DOI: 10.1111/j.1365-2125.1996.tb00153.x

PubMed id: 8824688


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