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9-cis retinoic acid - A better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma

Lookup NU author(s): Professor Penny Lovat, Professor Archibald Malcolm, Professor Andrew Pearson, Dr Chris RedfernORCiD


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To date, the clinical success of 13-cis or all-trans retinoic acid in the treatment of neuroblastoma has been disappointing. In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers. In vitro studies with an N-type neuroblastoma cell line, SH SY 5Y, show that 9-cis is better than other isomers at both inducing morphological differentiation and inhibiting proliferation. RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid. 9-cis and all-trans retinoic acid do not have synergistic effects on SH SY 5Y cell proliferation and gene expression. A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone. In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.

Publication metadata

Author(s): Lovat, P.E., Irving, H., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F.

Publication type: Article

Publication status: Published

Journal: Journal of Neuro-Oncology

Year: 1997

Volume: 31

Issue: 1-2

Pages: 85-91

Print publication date: 01/01/1997

ISSN (print): 0167-594X

ISSN (electronic): 1573-7373


DOI: 10.1023/A:1005785431343

PubMed id: 9049833


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